舒洛地特联合辛伐他汀治疗糖尿病下肢血管病变的疗效

Efficacy of sulodexide combined with simvastatin in the treatment of diabetic lower extremity vascular disease

目的探讨舒洛地特联合辛伐他汀治疗糖尿病下肢血管病变的疗效。方法将我院收治的116例糖尿病下肢血管病变患者随机分为两组,各58例。对照组采用舒洛地特治疗,观察组采用舒洛地特联合辛伐他汀治疗。比较两组患者的治疗效果。结果治疗后,两组患者血流速度、搏动指数、阻力指数均明显改善,且观察组优于对照组,差异具有统计学意义(P<0.05)。治疗后,两组患者的TC、TG及HDL-C水平均明显改善,且观察组优于对照组,差异具有统计学意义(P<0.05)。观察组患者无痛最大步行距离长于对照组,下肢VAS评分低于对照组(P<0.05)。结论舒洛地特联合辛伐他汀治疗糖尿病下肢血管病变效果较好,可有效改善患者下肢血流动力学状态,降低血脂水平,减轻疼痛,提高患者步行能力,值得临床选择。

Objective To investigate the efficacy of sulodexide combi ned with simvastatin in the treatment of diabetic lower extremity vascular disease. Methods A total of 116 diabetic patients with lower extremity vascular disease were randomly divided into two groups, with 58 cases in each group. The control group was treated with sulodexide, while the observation group was treated with sulodexide combined with simvastatin. The therapeutic effects of the two groups were compared. Results After treatment, the blood flow rate, pulsatility index and resistance index of the two groups significantly improved, and those of the observation group were superior to the control group, the differences were statistically significant（P〈0.05）. After treatment, the levels of TC, TG and HDL-C in both groups significantly improved, and those of the observation group were superior to the control group, the differences were statistically significant（P〈0.05）. The painless maximum walking distance of the observation group was longer than that of the control group, and the VAS score of the lower limbs was lower than that of the control group（P〈0.05）. Conclusion Sulodexide combined with simvastatin has a good clinical effect on diabetic lower extremity vascular disease, which can effectively improve the lower limb blood flow state and reduce blood lipid level, relieve pain, and increase walking ability of patients, which is worth clinical choice.