阿奇霉素序贯疗法+特步他林治疗小儿支原体肺炎的效果及对其细胞因子水平的影响

Effect of azithromycin sequential therapy and terbutaline on children with mycoplasma pneumonia and its impact on cytokines levels

目的探讨阿奇霉素序贯疗法+特步他林治疗小儿支原体肺炎的效果及对其细胞因子水平的影响。方法选择我院2015年8月至2017年12月收治的小儿支原体肺炎患儿86例为研究对象,根据患儿入院序号奇偶数将其分为对照组和观察组,各43例。对照组给予阿奇霉素序贯疗法治疗,观察组在此基础上联合特步他林治疗。对比两组患儿临床疗效、症状恢复时间和治疗前、后细胞因子水平。结果观察组治疗总有效率高于对照组(P<0.05)。观察组患儿发热、咳嗽、肺部啰音消失时间均短于对照组(P<0.05)。治疗后,两组患儿TNF-α、IL-6、IL-8水平均明显降低,且观察组低于对照组(P<0.05)。结论阿奇霉素序贯疗法+特步他林治疗小儿支原体肺炎效果显著,能促进患儿快速恢复,并改善其细胞因子水平,推荐推广。

Objective To investigate the effect of azithromycin sequential therapy and terbutaline on children with mycoplasma pneumonia and its impact on cytokines levels. Methods From August 2015 to December 2017, 86 children with mycoplasma pneumonia treated in our hospital were selected and divided into control group and observation group according to the odd and even number of admission, with 43 cases in each group. The control group was given azithromycin sequential therapy, and the observation group was treated with terbutaline on the basis of the control group. The clinical efficacy, symptom recovery time and cytokine levels before and after treatment were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group（P〈0.05）. The disappearance time of fever, cough and pulmonary rales in the observation group were shorter than those in the control group（P〈0.05）. After treatment, the levels of TNF-a, IL-6 and IL-8 in the two groups significantly decreased, and those of the observation group were lower than the control group（P〈0.05）. Conclusion Azithromycin sequential therapy and terbutaline in the treatment of children with mycoplasma pneumonia has a significant therapeutic effect, which can promote rapidly recovery of children and improve cytokine levels, and it is recommended for promotion.