光疗联合双歧杆菌三联活菌治疗新生儿高胆红素血症的临床效果

Clinical effect of phototherapy combined with bifid-triple viable in the treatment of neonatal hyperbilirubinemia

目的探讨光疗联合双歧杆菌三联活菌治疗新生儿高胆红素血症的临床效果。方法对180例新生儿高胆红素患儿的临床资料进行回顾性分析,按照治疗方法分为光疗组和联合组,各90例。光疗组新生儿仅给予蓝光治疗,联合组新生儿在此基础上联用双歧杆菌三联活菌治疗,对比两组治疗效果。结果联合组患儿的治疗总有效率显著高于光疗组,差异具有统计学意义(P<0.05);治疗前,两组患儿的血清TBIL水平比较,差异无统计学意义(P>0.05);治疗后,两组患儿的血清TBIL水平均明显降低,且联合组低于光疗组(P<0.05);联合组患儿的黄疸消退时间、平均住院时间、IgM及IgG水平均优于光疗组,差异具有统计学意义(P<0.05)。结论光疗联合双歧杆菌三联活菌治疗新生儿高胆红素血症的临床效果显著,能够快速降低血清TBIL水平,并提高机体免疫力。

Objective To investigate the clinical effect of phototherapy combined with bifid-triple viable in the treatment of neonatal hyperbilirubinemia. Methods The clinical data of 180 neonates with hyperbilirubinemia were retrospectively analyzed. According to the treatment methods, they were divided into phototherapy group and combined group, with 90 cases in each group. The neonates in the phototherapy group were given blu-ray treatment, on the basis of this, the newborns in the combined group were treated with bifid-triple viable, and the therapeutic effects of the two groups were compared. Results The total effective rate of treatment in the combined group was significantly higher than that of the phototherapy group, and the difference was statistically significant（P〈0.05）. Before treatment, there was no significant difference in the serum TBIL levels between the two groups（P〈0.05）. After treatment, the serum TBIL levels in both groups significantly decreased, and that in the combined group was lower than the phototherapy group（P〈0.05）. The jaundice regression time, average length of hospital stay, IgM and IgG levels in the combined group were better than those in the phototherapy group, the differences were statistically significant（P〈0.05）. Conclusion The phototherapy combined with bifid-triple viable in the treatment of neonatal hyperbilirubinemia has significant clinical effect. It can rapidly reduce the level of serum TBIL and improve the body immunity.