干细胞移植治疗天疱疮研究进展

Progress on stem cell transplantation for the treatment of pemphigus

天疱疮是一种可累及全身皮肤、黏膜的有潜在致死性的自身免疫性皮肤病。传统治疗方案包括糖皮质激素、免疫抑制剂、生物制剂等。疗效肯定且不断改进,但存在长期使用不良反应大、价格高昂等缺点,仍有其局限性。应用干细胞移植治疗重症天疱疮突破了传统治疗的局限,使根治天疱疮成为可能,正在成为新的研究热点。近年来的应用实例表明干细胞移植治疗天疱疮可行并且有效,而对移植相关的免疫学机制也有了初步的认识。

Pemphigus is a potentially fatal autoimmune disease involving mucous membrane and skin. Traditional treatments including glucocorticoids, immunosuppressants and biological agents are effective and have been improved in last decades, however long-term side effects and high price restrict theirs widespread application. Stem cell transplantation in patients with severe pemphigus, which breaks through the limitation of pharmacological therapy and makes complete remission possible, is becoming one of the hotspots in dermatology. Nowadays, there have been some studies demonstrated that stem cell transplantation in pemphigus is feasible and effective, while immunological mechanism behind transplantation has also been preliminarily interpreted in recent years.