酒石酸布托啡诺、盐酸曲马多及昂丹司琼注射剂体外配伍稳定性考察

Stability of in Vitro Compatibility of Butofenol Tartrate,Tramadol Hydrochloride and Ondansetron Injection

目的:考察酒石酸布托啡诺注射液、盐酸曲马多注射液及盐酸昂丹司琼注射液在0.9%氯化钠注射液中的配伍稳定性。方法:采用HPLC法测定配伍液中三种药物含量,考察三种药物在0.9%氯化钠注射液中,室温条件下72 h内的含量变化,同时观察与检测外观与pH变化。结果:酒石酸布托啡诺注射液、盐酸曲马多注射液及盐酸昂丹司琼注射液的配伍液在72 h内三种药物含量未见明显变化,配伍液外观澄清,pH值保持稳定。结论:酒石酸布托啡诺、盐酸曲马多及盐酸昂丹司琼在0.9%氯化钠注射液中室温条件下、72 h内保持稳定。

Objective：To investigate the compatible stability of butorphanol tartrate,tramadol hydrochloride and ondansetron hydrochloride in 0.9% sodium chloride injection.Methods：HPLC method was adopted to determine the content of 3 drugs in the compatibility solution.The content changes of 3 injections in 0.9% sodium chloride injection at room temperature for 72 hours were investigated,and changes of appearance and pH values were observed and tested.Results：The compatibility of butofenol injection,tramadol hydrochloride injection and ondansetron hydrochloride injection did not change significantly in the content of 3 drugs within 72 hours.The appearance of the compatibility solution was clarified and the pH values remained stable.Conclusion：Butorphanol tartrate injection,tramadol hydrochloride injection and ondansetron hydrochloride injection were stable in 0.9% sodium chloride injection at room temperature for 72 h.