摘要
目的:考察酒石酸布托啡诺注射液、盐酸曲马多注射液及盐酸昂丹司琼注射液在0.9%氯化钠注射液中的配伍稳定性。方法:采用HPLC法测定配伍液中三种药物含量,考察三种药物在0.9%氯化钠注射液中,室温条件下72 h内的含量变化,同时观察与检测外观与pH变化。结果:酒石酸布托啡诺注射液、盐酸曲马多注射液及盐酸昂丹司琼注射液的配伍液在72 h内三种药物含量未见明显变化,配伍液外观澄清,pH值保持稳定。结论:酒石酸布托啡诺、盐酸曲马多及盐酸昂丹司琼在0.9%氯化钠注射液中室温条件下、72 h内保持稳定。
Objective:To investigate the compatible stability of butorphanol tartrate,tramadol hydrochloride and ondansetron hydrochloride in 0.9% sodium chloride injection.Methods:HPLC method was adopted to determine the content of 3 drugs in the compatibility solution.The content changes of 3 injections in 0.9% sodium chloride injection at room temperature for 72 hours were investigated,and changes of appearance and pH values were observed and tested.Results:The compatibility of butofenol injection,tramadol hydrochloride injection and ondansetron hydrochloride injection did not change significantly in the content of 3 drugs within 72 hours.The appearance of the compatibility solution was clarified and the pH values remained stable.Conclusion:Butorphanol tartrate injection,tramadol hydrochloride injection and ondansetron hydrochloride injection were stable in 0.9% sodium chloride injection at room temperature for 72 h.
作者
冯云霞
李鹏
方宝霞
时晓亚
陈富超
Feng Yunxia;Li Peng;Fang Baoxia;Shi Xiaoya;Chen Fuchao(Dongfeng Hospital Affiliated to Hubei University of Medicine,Hubei Shiyan 442008,China)
出处
《儿科药学杂志》
CAS
2018年第9期29-32,共4页
Journal of Pediatric Pharmacy
基金
湖北省卫生计生科研基金项目
编号WJ2015MB290
十堰市科学技术研究与开发计划项目
编号16Y60
关键词
布托啡诺
曲马多
昂丹司琼
配伍
稳定性
butorphanol
tramadol
ondansetron
compatibility
stability