基于脑疲劳的Delta-Gamma相位幅值耦合研究

Research on Delta-Gamma Phase Amplitude Coupling Based on Mental Fatigue

脑疲劳是大脑长期处于精神高度集中后机体无法专心高效率完成任务的一种状态,极度影响着人们的生活和健康。但至今都没有简便有效的检测方法,而近期研究发现,低频与高频之间的相位幅值耦合(PAC)可能与相关脑认知活动的信息交流整合有关,可为脑疲劳检测提供新信息。对疲劳前后低频delta节律和高频gamma节律采用相位幅值耦合方法进行研究,使用Neuroscan 64导脑电仪采集脑电并用配对t检验对14名被试结果进行统计分析,结果显示,全脑区90%以上的delta相位共同调制多个脑区的gamma幅值,其中对前额叶区、顶枕叶区、顶叶区的耦合作用在脑疲劳后发生显著性下降,而对额叶区的耦合作用则显著上升。研究表明,delta-gamma相位幅值耦合值能很好地预测脑疲劳引起的宏观行为表现变化能力,为脑疲劳的检测提供新指标。

Mental fatigue is a state that a person cannot concentrate and finish the task efficiently because of long-term highly concentration on the work,which has extremely influenced upon the health and life of people.However,there have been no simple and effective detection methods. Meanwhile recent studies have found out that phase amplitude coupling（ PAC） between low and high rhythm may be related to the information integration in cognitive activities,providing new messages for the detection of mental fatigue.In this paper,the phase amplitude coupling between delta and gamma rhythm was used to study the EEG data recorded before and after mental fatigue. Neuroscan EEG system was used to collect data,and phase amplitude coupling of 14 subjects were calculated and analyzed by paired t test. The results showed that the delta phase of over 90% electrodeson the whole brain area jointly modulated gamma amplitude of frontal lobe,occipital lobe,parietal lobe and frontal lobe,and the coupling effect among different brain regions significantly increased in the first three subareas while the last region significantly decreased when participants were mental fatigued. This study showed that phase amplitude coupling could predict the change of macroscopic behavior caused by mental fatigue and provide a new index for the detection of mental fatigue.