中医药联合HAART干预艾滋病患者免疫重建不良的Meta分析

Meta-analysis of Traditional Chinese Medicine Combined with HAART Intervention for Poor Immune Reconstitution in AIDS Patients

目的:系统性评价中药制剂联合高效抗反转录病毒疗法(highly active anti-retroviral therapy,HAART)治疗艾滋病患者免疫重建不良的效果。方法:计算机检索中国知网、维普数据库、万方数据库、Pubmed,搜集中药制剂联合HAART治疗艾滋病患者免疫重建不良随机对照试验(randomized controlled trials,RCT)文献,根据改良版Jadad量表对纳入文献进行质量评价,使用Rev Man5.3软件对纳入文献进行Meta分析。结果:共纳入5个RCT文献,涉及761例患者,Meta分析结果显示,中药制剂联合HAART治疗艾滋病患者的CD_4^+T细胞变化情况,治疗组优于对照组{MD=31.61,95%CI=[16.73,46.49]},其治疗组有效率高于对照组{OR=2.07,95%CI=[1.51,2.85]}。结论:中药制剂联合HAART治疗艾滋病患者免疫重建不良的疗效优于单用HAART。

Objective： To systematically evaluate the effects of high-level Active Anti-Retroviral Therapy（ HAART） on AIDS patients with poor immune reconstitution. Methods： CNKI,VIP,Wanfang and Pub Med databases were searched,and the literature on drug preparations combined with HAART were used to treat randomized controlled trials（ RCT） of AIDS patients with immune reconstitution was obtained. According to the improved version of Jadad,the quality of the included literature was evaluated. Meta-analysis of the included literature was performed using Rev Man 5. 3 software. Results： A total of 5 RCTs were included in 761 patients. Meta-analysis showed that the changes of CD4~＋T cells in patients with AIDS treated with traditional Chinese medicine and HAART were significantly better than those in the control group（ MD = 31. 61,95% CI =[16. 73,46. 49]）,and that of the treatment group was more effective than that of the control group（ OR = 2. 07,95% CI =[1. 51,2. 85]）. Conclusion： The clinical efficacy of Chinese medicine combined with HAART is significantly better than that of HAART alone in treatment of AIDS patients with poor immune reconstitution.