宫颈癌患者人乳头瘤病毒感染分布情况及多重感染与临床病理特征的关系

The Distribution of Human Papillomavirus Infection and the Relationship between Multiple Infection and Clinicopathological Characteristics in Patients with Cervical Cancer

目的:研究宫颈癌患者人乳头瘤病毒(HPV)感染的分布情况及多重感染与临床病理特征的关系。方法:选择2015年1月-2018年1月期间我院收治的118例宫颈癌患者,根据患者宫颈癌的病变程度分为I期组(n=21)、II期组(n=46)、III期组(n=49)、IV期组(n=2)。所有患者均进行HPV分型检测,比较不同程度的宫颈癌患者的HPV感染情况,分析不同宫颈癌病变程度患者的多重感染和临床病理特征关系。结果:118例患者中有97例患者感染了HPV,感染率为82.20%,且II期组、III期组、IV期组患者HPV感染率高于I期组(P<0.05)。II期组、III期组、IV期组患者一重感染率低于I期组,IV期组二重感染率低于I期组,II期组、III期组、IV期组患者多重感染率高于I期组,且IV期组多重感染率高于II期组、III期组(P<0.05)。多重感染患者类型有多种,其中尤以HPV16+18+53型最多,占比49.05%,其次是HPV16+18+68型感染,占比32.07%,HPV16+53+58型感染,占比13.21%。年龄在50岁以上、分期为III-IV期、鳞癌、淋巴结转移的患者HPV多重感染率更高(P<0.05)。结论:HPV多重感染与宫颈癌病变程度和临床病理特征均有联系,对年龄较大且HPV多重感染的宫颈癌患者进行筛查,预防病情恶化。

Objective： To investigate the distribution of human papillomavirus（HPV） and the relationship between multiple infection and clinicopathological characteristics in patients with cervical cancer. Methods： 118 cases of cervical cancer who were treated in our hospital from January 2015 to January 2018 were selected. According to the degree of cervical cancer,they were divided into I stage group（n=21）,II stage group（n=46）,III stage group（n=49）,IV stage group（n=2）. All patients were detected by HPV typing,the HPV infection of cervical cancer patients in different degrees were compared,the relationship between multiple infections and clinicopathological characteristics of patients with different degrees of cervical cancer were analyzed. Results： Among the 118 patients,97 patients were infected with HPV,the infection rate was 82.20%,the HPV infection rate in II stage group,III stage group and IV stage group was higher than that of I stage group（P〈0.05）. The single infection rate of II stage group,III stage group and IV stage group was lower than that of I stage group,the double infection rate of IV stage group was lower than that of I stage group. The multiple infection rate in II stage group,III stage group and IV stage group were higher than that in I stage group,the multiple infection rate in IV stage group was higher than that in II stage group and III stage group（P〈0.05）. There were many types of multiple infection patients,most of them were HPV16＋18＋53 type,accounting for 49.05%,the second was type HPV16＋18＋68 infection,which accounted for 32.07%,type HPV16＋53＋58 infection,accounting for 13.21%,patients with age over 50 years,stage III-IV,squamous cell carcinoma and lymph node metastasis had higher HPV multiple infection rate（P〈0.05）. Conclusion： HPV multiple infection is associated with the degree and clinicopathological features of cervical cancer,screening for patients with older and multiple HPV infections to prevent the deterioration of the disease.