HPV病毒感染时间及型别与焦虑情绪障碍的相关性研究

Study on the correlations between HPV infection time,types and anxiety

目的探讨高危型人乳头瘤病毒(HPV)感染时间及型别与焦虑情绪障碍的相关性,为HPV感染人群制定个体化宣教策略提供科学依据。方法选取2017年1-6月在该院内镜中心因HPV病毒感染合并/不合并细胞学筛查结果异常就诊的523例患者为研究对象,根据是否存在焦虑情绪障碍分为病例组(134例)和对照组(389例),使用Logistic回归模型分析HPV感染持续时间及感染型别与焦虑的相关性。结果控制混杂因素后,与HPV病毒感染1年内患者相比,HPV感染持续1年及1年以上时间患者产生焦虑情绪的风险分别升高67%和98%(OR=1.67,95%CI:1.04～2.67;OR=1.98,95%CI:1.17～3.35),与低危HPV病毒亚型感染患者相比,HPV病毒16/18亚型感染患者发生焦虑情绪风险升高92%(OR=1.92,95%CI:1.08～3.41),按焦虑程度分层后,结果显示不同焦虑程度间HPV感染持续时间、HPV感染型别差异有统计学意义,且二者具有交互作用。结论 HPV病毒持续感染时间和高危型别感染增加焦虑情绪障碍的发生风险,持续高危型HPV病毒感染发生焦虑情绪障碍的风险显著高于低危HPV病毒短时间感染。应根据HPV感染持续时间及型别针对不同人群开展多层次、阶梯式、个体化的宣教和管理,降低HPV感染者焦虑情绪障碍的发生风险。

Objective To explore the correlations between high-risk human papillomavirus（ HPV） infection time,types and anxiety,provide a scientific basis for developing individualized propaganda and education strategies among HPV-infected population.Methods From January to June in 2017,523 patients with HPV infection combined with abnormal or normal cytological screening results were selected from Endoscopy Center in Gansu Provincial Maternal and Child Health Care Hospital,then the patients were divided into case group（ 134 patients） and control group（ 389 patients） according to complicated with anxiety or not. Logistic regression model was used to analyze the correlations between HPV infection time,types and anxiety. Results After controlling confounding factors,compared with the patients with HPV infection within one year,the risks of anxiety in patients with HPV infection for one year and more than one year increased by 67% and 98%,respectively（ OR = 1. 67,95% CI： 1. 04-2. 67; OR = 1. 98,95% CI： 1. 17-3. 35）. Compared with the patients with low-risk HPV subtypes infection,the risk of anxiety in patients with HPV 16/18 infection increased by 92%（ OR = 1. 92,95% CI： 1. 08-3. 41）. The patients were stratified by the degree of anxiety,there were statistically significant differences in duration time of HPV infection and HPV infection types among the patients with different degrees of anxiety,which had interaction. Conclusion The duration time of HPV infection and high-risk HPV subtype infection can increase the risk of anxiety in patients,the risk of anxiety in patients with persistent highrisk HPV infection is significantly higher than that in patients with short-term low-risk HPV infection. Multilevel,multistep,and individualized propaganda,education,and management should be conducted among various populations according to duration time of HPV infection and HPV subtypes to reduce the risk of anxiety among patients with HPV infection.