原发性开角性青光眼与高度近视的相关性

Research on the correlation of primary open-angle glaucoma and high myopia

目的探索原发性开角性青光眼(POGA)与高度近视患者的临床特点及其相关性。方法回顾性分析57例(98眼)POGA和59例(97眼)非POGA患者的近视状况及其相关性。比较两组患者的近视率和在不同视力的情况下患者眼底4个象限平均光敏感度。结果两组高度近视、中低度近视和正常视力情况的分布差异有统计学意义(Z=-5.424,P<0.001);POGA组近视率(77.56%)明显高于非POAG组(63.92%),组间差异有统计学意义(χ~2=4.380,P<0.05)。POAG组的高度近视率(25.51%)明显高于非POAG组(9.28%),组间差异有统计学意义(χ~2=8.922,P<0.05)。在不同视力水平的情况下,POAG组患者眼底4个象限平均光敏感度均差异有统计学意义(P<0.05)。POAG组中,高度近视和中低度近视患者的眼压与角膜厚度和眼轴长度之间存在显著的相关关系(r_1=0.262、0.224;r_2=0.183、0.167;均P<0.05);非POAG组中,高度近视患者的眼压与角膜厚度和眼轴长度之间存在显著的相关关系(r_1=0.206;r_2=0.135;均P<0.05)。结论 POGA与高度近视具有较高的相关性,POAG患者同时伴有高度近视的发生率较高。

Objective To study the clinical charaCTeristics and correlations of primary open angle glaucoma（ POGA） and high myopia.Methods The myopia status and correlation of 57 cases（ 98 eyes） with POGA and 59 cases（ 97 eyes） of non POGA were retrospeCTively analyzed. The myopia rate and the mean light sensitivity of four quadrants in different visual acuity were compared between the two groups. Results The distribution of moderate and low myopia and normal visual acuity was significantly different between the two groups（ Z =-5. 424,P〈0. 001）; the myopia rate of POGA group（ 77. 56%） was significantly higher than that of non-POGA group（ 63. 92%）,and the difference between the two groups was statistically significant（ χ~2= 4. 380,P〈0. 05）,the rate of high myopia in POGA group（ 25. 51%） was significantly higher than that in non-POGA group（ 9. 28%）,and the difference between the two groups is statistically significant（ χ~2= 8. 922,P〈0. 05）; there was significant differences in the mean light sensitivity of the four quadrants in POGA group with different visual acuity levels（ P〈0. 05）. In POGA group,there was a significant correlation between intraocular pressure（ IOP） and corneal thickness and eye axis length in patients with high myopia and low to moderate myopia（ r1= 0. 262,0. 224;r2= 0. 183,0. 167,P〈0. 05）; In the non-POGA group,there was a significant correlation between IOP and corneal thickness and axial length in patients with high myopia（ r1= 0. 206; r2= 0. 135,P〈0. 05）. Conclusions POGA has a high correlation with high myopia high,POAG patients have a high incidence of high myopia.