血清中抗氧化剂水平与腰椎骨赘形成的相关性研究

Relationships of levels of serum antioxidants with osteophyte formation

目的探讨血清中维生素A、E以及β-类胡萝卜素的含量与腰椎骨赘形成是否存在相关性。方法对2015年1月至2016年1月在广东医科大学附属湛江中心人民医院进行健康体检的符合纳入及排除标准的社会人群进行顺序编号,按照随机数字表法获取200例作为研究对象,男性72例,女性128例,平均年龄68岁,记录其饮酒史以及吸烟史等。通过X光扫描获得其腰椎侧位平片,并测量其腰椎前凸角、骶骨倾斜角。同时检测试验对象血清中的维生素A、E、β-类胡萝卜素含量、三酰甘油水平、体质量指数(BMI)、骨质疏松症程度。结果通过X光扫描发现有34例体检对象有腰椎骨赘形成,约占总人数17%。嗜酒的老年男性尤为显著,并且与骶骨倾斜角大小有显著相关性。同时,腰椎骨赘形成者的血清中,维生素E以及β-类胡萝卜素的水平显著低于其他体检人群。logistic回归分析显示高龄[优势比(OR)=1.1,95%置信区间(CI)=1.02~1.16;P=0.026]以及血清中低维生素E(OR=2.3,95%CI=1.08~10.9;P=0.013)与β-类胡萝卜素水平(OR=6.7,95%CI=1.39~32.6;P=0.021)均是普通人群中骨赘形成的危险因素。结论血清中低维生素E及β-类胡萝卜素水平下降是腰椎骨赘形成的重要危险因素,提示在这个快速老龄化的社会中,我们应该通过合理的营养摄入来防止腰椎骨赘形成及退变性疾病的发生。

Objective To investigate the relationships of levels of serum vitamin A,vitamin E and β-carotene with osteophyte formation. Methods From January 2015 to January 2016,the social populations who met the inclusion and exclusion criteria for health checkups at the Zhanjiang Central People＇s Hospital affiliated to Guangdong Medical University were serially numbered. According to the random number table method,200 cases were obtained as the objeCTs of study（ male 72 cases,female 128 cases,average age 68 years old）,and their drinking history and smoking history were recorded. The lumbar lateral flat plate was obtained by X-ray scanning,and the lumbar lordosis angle and the sacral tilt angle were measured. Meanwhile,the contents of serum vitamin A,E,beta carotene,triglyceride level,body mass index（ BMI） and osteoporosis degree were deteCTed. Results X-ray scan showed that 34 patients had lumbar vertebrae formation,accounting for 17% of the total number. Osteophyte formation was particularly significant in older men,and had a significant correlation with the size of the sacral tilt angle. At the same time,the levels of serum vitamin E and β-carotene of patients with lumbar vertebrae formation were significantly lower than those of other physical examination population. Logistic regression analysis showed that older age [odds ratio（ OR） = 1. 1,95% confidence interval（ CI） = 1. 02-1. 16,P = 0. 026） ]and a low vitamin E in serum（ OR = 2. 3,95% CI 1. 08-10. 9; P = 0. 013） and a low β-carotene in serum（ OR = 6. 7,95% CI = 1. 39-32. 6; P = 0. 021） were risk faCTors for osteophyte formation in the general population. Conclusions The low levels of serum vitamin E and β-carotene were important risk faCTors for lumbar osteophytes. This finding suggests that appropriate dietary intake of antioxidants is important for inhibition of lumbar osteophytes and lumbar degenerative diseases in a rapidly aging society.