博来霉素致过敏性休克1例

Bleomycin induced allergic shock: an analysis of a case

目的为临床处理博来霉素致过敏性休克提供经验参考。方法报道1例博来霉素致过敏性休克,结合博来霉素的药理作用和临床用药情况,针对该患者个体特点对病例进行分析。结果该患者为霍奇金淋巴瘤,输注博来霉素过程中出现了严重的过敏性休克反应(血压下降、呼吸困难、意识丧失、四肢湿冷、多汗等)及心律失常,经无创呼吸机辅助呼吸、升压、扩容、补液、镇静、抗心律失常等治疗后患者生命体征逐步平稳,休克得以纠正,无其他不良反应。结论医护人员在计划使用博来霉素时就应提高警惕,仔细阅读说明书,了解药品的注意事项和不良反应,尤其初次使用患者。

Objective To provide experience reference for clinical treatment of allergic shock induced by bleomycin. Methods We analyzed the individual charaCTeristics of the patients combining the pharmacological aCTion and clinical medication of bleomycin. Results A patient with Hodgkin lymphoma received intravenous dripped bleomycin for treatement. During the process the patient had serious allergic shock（ including lowered blood pressure,dyspnea,loss of consciousness,coolness of extremities,hidrosis,et al.） and arrhythmia. After the treatment of non-invasive ventilator assisted respiration,pressure lifting,volume enlargement,rehydration,sedation and anti-arrhythmia,the patient＇s vital signs gradually stabilized,and the shock was correCTed without any other adverse events. Conclusions Medical staff should be alert when planning to use bleomycin by reading the instruCTions carefully to know about the precautions and adverse events of the drug,especially for initial use of the patient.