逍遥散加减联合七白散治疗女性肝郁气滞型黄褐斑疗效观察

Clinical Observation of Xiaoyao Powder combine with Qibai Powder in the Treatment of Liver Depression and Qi Stagnation Type Melasma

目的:观察逍遥散加减内服联合七白散面膜治疗女性肝郁气滞型黄褐斑患者的疗效、复发率及安全性。方法:采用随机数字表法将符合标准的91例患者分为3组,联合组(采用逍遥散加减内服联合七白散面膜)31例,中药组(逍遥散加减内服)30例,面膜组(七白散面膜)30例,每4周为1个疗程,共观察3个疗程。结果:联合组患者在治疗4周、8周、12周末的有效率分别为45.16%、61.29%、74.19%;中药组的有效率分别16.67%、43.33%、50%;面膜组的有效率分别为6.67%、20%、26.67%。3组患者治疗4周后疗效比较有统计学差异(P<0.05),联合组最优,中药组和面膜组比较无差异;治疗后8周、12周末,联合组>中药组>面膜组,且3组均未见严重的不良反应。结论:逍遥散加减内服联合七白散面膜治疗女性肝郁气滞型黄褐斑疗效确切,复发率低,是治疗黄褐斑安全有效的方法之一。

Objective：To observe the curative effect,recurrence rate and safety of Xiaoyao powder combined with Qibai powder in the in the treatment of liver depression and Qi stagnation type melasma in women.Methods：A total of 91 patients who met the criteria were divided into 3 groups by random number table method.The combined group（Xiaoyao powder orally combined with Qibai powder） 31 cases,the Chinese medicine group（Xiaoyao powder orally） 30 cases,mask There were 30 cases（Qibai powder masks）,one course every 4 weeks,and a total of 3 courses were observed.Results：The effective rates of the combined group at 4 weeks,8 weeks,and 12 weeks were 45.16%,61.29%,and 74.19%,respectively.The effective rate of the Chinese medicine group was 16.67%,43.33%,and 50%,respectively.The effective rate of the mask group was 6.67%,20%,and 26.67%,respectively.After 4 weeks of treatment,the efficacy of the three groups was statistically different（P〈0.05）.The combination group was the best,and there was no difference between the Chinese medicine group and the mask group.At 8 weeks and 12 weeks after treatment,the combination group 〉 Chinese medicine group 〉 mask group,and no serious adverse reactions were observed in the 3 groups.Conclusion：Xiaoyao powder combined with Qibai powder mask is effective in treating female patients with liver Qi stagnation and chloasma,and the recurrence rate is low.It is one of the safe and effective methods for treating chloasma.