非酒精性脂肪性肝病与肠道菌群的关系

Relationship between non-alcoholic fatty liver disease and intestinal flora

非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)是一种多病因导致的临床病理综合征,已成为最常见的慢性肝病之一,目前NAFLD完整的生理机制尚不完全清楚,近年来提出肠道菌群通过调控能量代谢、增加内源性乙醇、调节胆汁酸及胆碱代谢,破坏免疫平衡引发机体低度炎症等途径促进NAFLD的发生、发展,本文就肠道菌群与NAFLD的相关机制做一概述。

Non-alcoholic fatty liver disease（NAFLD）is a clinical pathological syndrome caused by multiple etiologies.It has become one of the most common chronic liver diseases.The complete physiological mechanism of NAFLD is not fully understood.The recent researches suggest that intestinal flora can promote the occurrence and development of NAFLD by regulating the energy metabolism,increasing the endogenous ethanol,adjusting metabolism of bile acid and choline,damaging the immune balance and triggering the low-grade inflammation.This paper summarizes the mechanism of intestinal flora and NAFLD.