丹郁消癖颗粒水煎提取工艺的研究

Optimization of extraction technology of Danyu Xiaopi granules

目的:优选丹郁消癖颗粒水煎提取工艺。方法:采用L_9(3~4)正交试验,以丹参素钠含量和干膏率为综合评价指标,以加水倍数、提取次数和提取时间为考察因素,优选丹郁消癖颗粒的水煎提取参数并进行验证试验。结果:丹郁消癖颗粒最优提取工艺为试验药材加10倍量水,提取3次,每次2h。验证试验中干膏率平均值为26.85%(RSD=1.30%,n=3)、丹参素钠含量平均值为146.61mg(RSD=2.06%,n=3)。结论:优选的水煎提取工艺稳定可行,可为丹郁消癖颗粒的标准化、规范化生产提供依据。

Objective：To optimize the extraction technology of Danyu Xiaopi granules.Methods： L 9 （3^ 4 ）orthogonal test was used,using the comprehensive evaluation result of the content of salvianic acid A sodium and paste rate as index,water amount,extraction times,extracting time as factors,extraction technology of Danyu Xiaopi granules was optimized,and the verification test was conducted.Results：The optimal extraction technology of Danyu Xiaopi granules was as follows as 10-fold water,extracting for 3 times,2 hour each time.The validation results showed that the average paste rate was 26.85%（RSD=1.30%, n =3）,and the average content of salvianic acid A sodium was 146.61mg（RSD=2.06%, n =3）.Conclusion：The optimized extraction technology is stable and can provide the basis for standardized production technology of Danyu Xiaopi granules.