三磷酸鸟苷环化水解酶1和四氢生物蝶呤与神经性疼痛的研究进展

Research advances of the relationship between the GTP cyclohydrolase 1, tetrahydrobiopterin and neuropathic pain

神经性疼痛是临床最常见的慢性疼痛之一,针对其治疗一直以来都是全球的难点,主要原因是其发病机制不明.三磷酸鸟苷环化水解酶1（GCH1）通过调节相关炎性因子介导神经性疼痛的发生,除此之外GCH1也是四氢生物蝶呤（BH4）合成过程中最主要的限速酶.BH4是各种炎性因子和神经递质合成必需的辅因子.在研究其与疼痛的关系时,发现当沉默GCH1基因后伴随疼痛缓解,BH4表达降低.结果提示GCH1和BH4与神经性疼痛有一定的关系.

Neuropathic pain is one of the most common chronic pain in clinic, and its treatment has always been a global difficulty, mainly because its pathogenesis is unknown. GTP cyclohydrolase 1 （GCH1） mediated neuropathic pain by regulating inflammatory cytokines. Besides, GCH1 is also the main speed limit in the process of tetrahydrobiopterin （BH4） enzyme synthesis. BH4 is a necessary cofactor for the synthesis of various inflammatory factors and neurotransmitters. In the study of its relationship with pain, it was found that when the GCH1 gene was silent, the pain was relieved and the expression of BH4 decreased. The results suggest that GCH1 and BH4 have a certain relationship with neuropathic pain.