实体肿瘤消融的免疫效应及联合免疫治疗的临床研究现状

Effect of ablation of solid tumors on immune function: Clinical application of combined immunotherapy

随着医学的不断进步,消融作为一种实体肿瘤微创治疗技术,而大量应用于临床并获得较好疗效.肿瘤消融亦可对肿瘤微环境产生影响,从而为肿瘤特异性免疫识别提供一个良好的环境,而联合免疫治疗可进一步增强其抗肿瘤免疫效应,改善长期疗效.关于肿瘤消融对机体免疫功能的影响以及免疫联合治疗近年来成为研究的热点,在临床病例中的应用逐渐增加,本文重点针对实体肿瘤消融的免疫效应及联合免疫治疗的临床研究文献进行总结,分析其临床应用现状.

Ablation, as a minimally invasive therapy for solid tumors, has been widely used in clinical practice and achieved satisfactory outcome. Tumor ablation has an effect on the tumor microenvironment so that a good environment for tumor specific immune recognition can be provided. Thus, combined immunotherapy can enhance the antitumor immune effect and improve the long-term outcome. The effect of tumor ablation on the immune function of the body and the combination of immunotherapy have become a hot topic in recent years. In this article, we will summarize the related clinical studies and comments on the effect of ablation of solid tumors on immune function and the status of combined immunotherapy.