自噬参与肝纤维化的机制

Mechanism of autophagy in liver fibrosis

自噬是细胞依赖溶酶体的一种代谢过程,通过分解细胞内蛋白质、脂质等成分,循环再利用分解产物,使细胞适应不利的生活环境,是机体维持内环境稳态的重要机制.肝纤维化是指肝组织内细胞外基质成分过度增生与异常沉积,导致肝脏结构和功能异常的病理变化,肝纤维化见于多数不同病因的慢性肝脏疾病中.本文总结了自噬参与肝纤维化的作用以及与肝纤维化相关的自噬信号通路,进一步阐述细胞自噬参与肝纤维化的机制.

Autophagy is an evolutionarily conserved lysosomedependent catabolic process which degrades cell components, including proteins and lipids, in order to recycle substrates to exert optimally and adapt to tough circumstances. It is an important mechanism for the body to maintain the homeostasis of the internal environment. Liver fibrosis refers to the excessive proliferation and abnormal deposition of extracellular matrix components in the liver tissue, resulting in pathological changes in liver structure and function abnormalities, which is seen in chronic liver diseases of many different causes. In this article, we summarizes the role of autophagy in hepatic fibrosis as well as the relevant signaling pathways to reveal the mechanism of autophagy in hepatic fibrosis.