期刊文献+

GLP-1受体激动剂艾塞那肽治疗2型糖尿病患者的临床研究 被引量:1

下载PDF
导出
摘要 目的探讨2型糖尿病患者采取GLP-1受体激动剂艾塞那肽治疗的临床效果。方法抽取我院收治的2型糖尿病患者80例作为研究对象,纳入时间2016年5月—2018年1月,有完整临床资料,愿意配合研究,按照1:1比例分组,每组40例。对照组患者采取二甲双胍联合吡格列酮治疗,观察组在对照组基础上加用GLP-1受体激动剂艾塞那肽治疗。治疗与治疗后均测定患者的空腹血糖、餐后2h血糖、糖化血红蛋白,并记录不良反应情况,采取统计学处理。结果两组患者在治疗前空腹血糖、餐后2h血糖、糖化血红蛋白对比差异不显著(P>0.05),治疗后观察组前述指标均显著优于对照组(P<0.05);两组治疗期间均有不良反应发生,但比较轻微,且组间比较差异不明显(P>0.05)。结论 2型糖尿病患者接受GLP-1受体激动剂艾塞那肽治疗,不仅可以更好地改善患者的血糖指标,而且安全性高,值得推荐。
作者 宋惠杰
机构地区 武汉市第一医院
出处 《泰山医学院学报》 CAS 2018年第10期1149-1150,共2页 Journal of Taishan Medical College
  • 相关文献

参考文献6

二级参考文献57

  • 1李霞,周智广,亓海英,陈小燕,黄干.用空腹C肽代替胰岛素改良Homa公式评价胰岛素抵抗和胰岛β细胞功能[J].中南大学学报(医学版),2004,29(4):419-423. 被引量:212
  • 2Buse JB,Henry RR,Han J,et al.Effects of exenatide on glycemic control over 30 weeks in sulfonylurea treated patients with type 2 diabetes[J].Diabetes Care,2004,27(11):2628-2635.
  • 3Kendall DM,RiddleMC,Rosenstock J,et al.Effects of exenatide on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea[J].Diabetes Care,2005,28(5):1083-1091.
  • 4Defronzo RA,Ratner RE,Han J,et al.Effects of exenatide on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes[J].Diabetes Care,2005,28 (5):1092-1100.
  • 5Blonde L,Klein EJ,Han J,et al.Interim analysis of the effects of exenatide treatment on A1C,weight and cardiovascular risk factors over 82 weeks in 314 overweight patients with type 2 diabetes[J].Diabetes Obes Metab,2006,8(4):436-447.
  • 6Klonoff DC,Buse JB,Nielsen LL,et al.Exenatide effects on diabetes,obesity,cardiovascular risk factors and hepatic biomarkers in patients with type 2 diabetes treated for at least 3 years[J].Curr Med Res Opin,2008,24(1):275-286.
  • 7Yoon NM,Cavaghan MK,Brunelle RL,et al.Exenatide added to insulin therapy:a retrospective review of clinical practice over two years in an academic endocrinology outpatient setting[J].Clin Ther,2009,31(7):1511-1523.
  • 8Sheffield CA,Kane MP,Busch RS,et al.Safety and efficacy of exenatide in combination with insulin in patients with type 2 diabetes mellitus[J].Endocr Pract,2008,14(3):285-292.
  • 9Nayak UA,Govindan J,Baskar V,et al.Exenatide therapy in insulin-treated type 2 diabetes and obesity[J].QJM,2010,103(9):687-694.
  • 10American Diabetes Association.Standards of medical care in diabetes-2011[J].Diabetes Care,2011,34(Suppl 1):S11-S61.

共引文献88

同被引文献17

引证文献1

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部