老年人骨骼肌减少症与动脉粥样硬化的关系

Relationship between sarcopenia and atherosclerosis in the elderly

目的探讨老年人骨骼肌减少症与动脉粥样硬化的关系。方法选择年龄≥60岁的老年人203例,根据相对骨骼肌质量指数(RSMI)分为少肌症组103例与非少肌症组100例,入组对象均进行体格检查、骨密度检查、实验室检查。结果少肌症组男性、四肢骨骼肌量(ASM)明显低于非少肌症组,年龄、身高、体质量指数、Crouse积分、颈动脉内膜中层厚度(cIMT)、半定量积分、等级积分、斑块数量、TG及LDL-C水平明显高于非少肌症组,差异有统计学意义(P<0.05,P<0.01)。Spearman相关分析结果显示,RSMI与身高(r=0.447,P=0.000)和ASM(r=0.471,P=0.000)呈正相关,与性别(r=-0.866,P=0.000)、年龄(r=-0.229,P=0.000)、BMI(r=-0.147,P=0.036)、cIMT(r=-0.636,P=0.000)、Crouse积分(r=-0.633,P=0.000)、半定量积分(r=-0.601,P=0.000)、等级积分(r=-0.698,P=0.000)、斑块数量(r=-0.667,P=0.000)、TG(r=-0.194,P=0.006)呈负相关,且RSMI与LDL-C无关(P>0.05)。多重线性回归分析显示,各因素对RSMI的影响由大到小依次为性别、身高、ASM、cIMT、斑块数量、等级积分、半定量积分(P<0.05,P<0.01)。结论老年人伴发骨骼肌减少症与动脉粥样硬化的程度有关。

Objective To study the relationship between sarcopenia and atherosclerosis in the elderly.Methods Two hundred and three≥60 years old people were divided into sarcopenia group（n=103）and sarcopenia-free group（n=100）according to their RSMI.They underwent physical examination,bone mineral density measurement and laboratory testing.Results The number of males and appendicular skeletal muscle（ASM）were significantly smaller,the age was significantly older,the body height,BMI,Crouse score,semiquantitative integral,grade integral,serum TG and LDL-C level were significantly higher,the cIMT was significantly thicker,the number of plaques was significantly greater in sarcopenia group than in sarcopenia-free group（P〈0.05,P〈0.01）.Spearman correlation analysis showed that RSMI was positively related with body height and ASM（r=0.447,P=0.000;r=0.471,P=0.000）,negatively related with gender,age,BMI,cIMT,Crouse score,semiquantitative integral,grade integral,number of plaques and serum TG level（r=-0.866,P=0.000;r=-0.229,P=0.000;r=-0.147,P=0.036;r=-0.636,P=0.000;r=-0.633,P=0.000;r=-0.601,P=0.000;r=-0.698,P=0.000;r=-0.667,P=0.000;r=-0.194,P=0.006）,but not related with serum LDL-C level（P〉0.05）.Multiple linear regression analysis showed that RSMI was first affected by sex followed by body height,ASM,cIMT,number of plaques,hierarchical integral and semiquantitative integral（P〈0.05,P〈0.01）.Conclusion Sarcopenia is related with atherosclerosis in the elderly.