丁苯酞用于治疗急性脑梗死临床疗效及安全性观察

Clinical Efficacy and Safety Observation of Application of Butylphthalide in Treating Acute Cerebral Infarction

目的:探讨丁苯酞治疗急性脑梗死治的疗效及安全性。方法:前瞻性收集急性脑梗死患者368例,按随机数字表法分为实验组和对照组,各184例,对照组患者予常规治疗,实验组患者另加用丁苯酞胶囊治疗,比较两组患者疗效和安全性。结果:实验组患者治疗总有效率高于对照组(P<0.05);两组患者治疗前NIHSS、ADL评分差异无统计学意义;两组患者治疗后较治疗前NIHSS评分明显降低,ADL评分明显增高(P<0.05);治疗后实验组NIHSS评分、ADL评分明显优于对照组(P<0.05)。两组患者不良反应发生率差异无统计学意义。结论:丁苯酞胶囊用于治疗急性脑梗死效果确切,安全性好。

Objective：To observe the clinical efficacy and safety of butylphthalide in the treatment of acute cerebral infarction. Methods：368 patients with acute cerebral infarction were randomly divided into study group and control group according to the method of random number table, 184 cases in each group.The study group used Butylphthalide on the basis of routine treatment, while the control group only received routine treatment.The study was to observe the clinical efficacy and drug safety. Results： The total effective rate in the observation group was obviously better than that in the control group（P〈0.05）, and the differences in the NIHSS score and ADL score between the two groups before treatment had no statistical significance, after treatment, the NIHSS score obviously decreased but the ADL score obviously increased, and the differences had statistical significance（P〈0.05）, after treatment,There was no significant difference in incidence of adverse reactions. Conclusion：Butylphthalide proves a good curative effect and good security in the treatment of acute cerebral infarction.