瓜环基主客体探针对金属离子的识别和响应

Recognition and Response of Metal Cations by Cucurbit[n]Urils-based Host-Guest Probes

瓜环具有接近电中性的空腔和负电性羰基端口的结构特征,这不仅能使瓜环(空腔)包结不同的客体分子形成主客体包结配合物,还能使瓜环(端口)与金属离子配位形成配合物,从而形成了以瓜环主客体化学为主流、瓜环配位化学为辅的瓜环化学格局。然而金属离子的存在可能影响瓜环主客体相互作用,或竞争削弱瓜环主客体相互作用或协同促进瓜环主客体相互作用,从而使原有瓜环主客体性质发生改变。本文抓住这一特性,对国内外以及重点实验室在这方面研究进行较全面的归纳和总结,并拟开展"瓜环基主客体探针对金属离子的识别和响应"的研究课题,为瓜环化学开辟一个新的研究方向。

Cucurbit[n]urils（ hereafter abbreviated as Q[n]s） are characteristic of cavities that are almost to a electrically neutral state and negative electro-potential portals rimmed with carbonyl groups. This can not only make Q[n]s（ cavities） include various guest molecules to form Q[n]-based host-guest inclusion complexes,but also make cucurbit[n]uril（ portals） coordinate with metal cations to form Q[n]-based coordination complexes,forming the pattern with Q[n]-based host-guest chemistry as the mainstream and Q[n]-based coordination chemistry as the supplement,the developing branch in the cucurbit[n]uril chemistry. However,metal cations may affect Q[n]-based host-guest inclusion interactions. They will compete each other to weaken Q[n]-based hostguest inclusion interactions or coordinate to facilitate Q[n]-based host-guest inclusion interactions so that the properties of inclusion complexes are changed. Thus,a thorough summary was made on the researches of this field from the key laboratory and other laboratories at home and abroad. The research ＂recognition and response of metal cations by Q[n]-based host-guest probes＂will be conducted to set out a new direction for cucurbit[n]uril chemistry.