胞二磷胆碱与阿司匹林联合丁苯酞氯化钠注射液对急性缺血性脑卒中患者神经功能缺损及生活质量的影响

Effect of Citicoline and Aspirin Combined with Butylphthalide and Sodium Chloride Injection on Neurological Deficit and Quality of Life in Patients with Acute Ischemic Stroke

目的研究胞二磷胆碱与阿司匹林联合丁苯酞氯化钠注射液对急性缺血性脑卒中患者神经功能缺损及生活质量的影响。方法选取2015年12月至2017年11月驻马店市第四人民医院急性缺血性脑卒中患者420例,依照治疗方案不同分为观察组(n=210)和对照组(n=210)。对照组采用胞二磷胆碱与阿司匹林治疗,观察组采用胞二磷胆碱与阿司匹林联合丁苯酞氯化钠注射液治疗。比较两组疗效、治疗前后神经功能缺损程度、生活质量及血流动力学[最大峰值流速(Vs)、平均流速(Vm)、血管阻力指数(RI)]变化。结果观察组治疗总有效率93.33%,高于对照组74.29%,差异有统计学意义(P<0.05);治疗后观察组RI、Vs、Vm优于对照组,差异有统计学意义(P<0.05);治疗后观察组卒中量表(NIHSS)评分低于对照组,健康状况简明量表(SF-36)评分高于对照组,差异有统计学意义(P<0.05)。结论急性缺血性脑卒中患者采用胞二磷胆碱与阿司匹林联合丁苯酞氯化钠注射液治疗疗效显著,能有效降低其神经功能缺损程度,改善血流动力学,提高生活质量。

Objective To investigate the effect of the citicoline and the aspirin combined with the butylphthalide and sodium chloride injection on the neurological deficit and the quality of life in patients with acute ischemic stroke.Methods From December 2015 to November 2017,420 patients with acute ischemic stroke in Fourth People＇s Hospital of Zhumadianl were divided into the observation group（n=210）and the control group（n=210）according to different treatment plans.The control group was treated with citicoline and the aspirin,and the observation group was treated with citicoline and the aspirin combined with butylphthalide and sodium chloride injection.The efficacy,the degree of the neurological deficit,the quality of life and the changes of hemodynamics[maximum peak velocity（Vs）,average velocity（Vm）,vascular resistance index（RI）] before and after treatment were compared between the two groups.Results The total effective rate of the observation group [93.33%（196/210）] was higher than that of the control group [74.29%（156/210）].The differences were statistically significant（P〈0.05）.After the treatment,the RI,Vs and Vm of the observation group were superior to those of the control group.The differences were statistically significant（P〈0.05）.After the treatment,the score of Stroke Scale（NIHSS）of the observation group was lower than that of the control group,and the score of the health status scale（SF-36）was higher than that of the control group.The differences were statistically significant（P〈 0.05）.Conclusion The effect of the citicoline and the aspirin combined with the butylphthalide and sodium chloride injection in patients with acute ischemic stroke is significant.It can effectively reduce the degree of the neurological deficit,improve the hemodynamics and improve the quality of life.