自身免疫性溶血性贫血转变为边缘区淋巴瘤的可能机制分析

Analysis of possible mechanisms of autoimmune hemolytic anemia in marginal lymphoma

目的探讨自身免疫性疾病与恶性淋巴瘤的关系。方法对收治的一例自身免疫性疾病转变为恶性淋巴瘤的患者临床资料及相关文献进行复习分析。结果患者有9年的自身免疫性溶血性贫血病史,长时间应用糖皮质激素治疗,病程中曾感染EB病毒,最后通过骨髓免疫分型以及骨髓活检免疫组化诊断边缘区淋巴瘤。结论自身免疫性溶血性贫血逐渐演变为边缘区淋巴瘤病例临床罕见,其发病机制可能与病毒感染、免疫功能异常、免疫抑制剂应用、免疫监视失控等有关。

Objective To study the relationship between autoimmune disease and malignant lymphoma.Methods The clinical data of a patient with autoimmune disease complicated with malignant lymphoma and the relevant literature were analyzed.Results The patient had a history of autoimmune hemolytic anemia for 9 years and had been treated with glucocorticoid for a long time.The EB virus was infected in the course of the disease.Finally,the marginal lymphoma was diagnosed by bone marrow immunophenotyping and bone marrow biopsy.Conclusion Autoimmune hemolytic anemiagradually evolved into the marginal area of lymphoma cases is rare.The pathogenesis may be associated with viral infection,immune dysfunction,immunosuppressant applications,immune surveillance out of control and so on.