寿胎丸加减治疗黄体功能不全型先兆流产及其对细胞因子影响

Observation of Shoutai Pill in the Treatment Luteal Phase Defect Threatened Abortion and Its Effect on Cytokines

目的：探讨寿胎丸加减治疗黄体功能不全型先兆流产及其对细胞因子的影响。方法：收集我院收治的黄体功能不全型先兆流产患者86例,依据随机数字表法随机分为对照组和治疗组,各43例,对照组予以肌注黄体酮注射液、口服地屈孕酮片等对症治疗;治疗组在对照组的基础上予以寿胎丸加减治疗,两组患者均连续治疗2周为1个疗程。比较两组患者临床疗效,腰酸腹痛缓解及止血时间,P、HCG及E2含量,血清IL-17、IL-10及TNF-α水平情况。结果：治疗后,治疗组临床总有效率为93.02%,对照组临床总有效率为74.42%,治疗组较对照组改善明显,两组结果具有显著差异（P〈0.05）;两组患者腰酸腹痛缓解及止血时间均缩短,治疗组较对照组缩短明显,两组结果具有显著差异（P〈0.05）;两组患者P、HCG及E2含量均有所升高,治疗组较对照组升高明显,差异具有统计学意义（P〈0.05）;两组患者血清IL-17、IL-10及TNF-α水平均有所降低,相对于对照组,治疗组患者降低更明显（P〈0.05）。结论：寿胎丸加减具有补肾安胎、益气健脾、调补冲任的作用,对于脾肾两虚型黄体不全引起的先兆流产起到较好的临床疗效,值得临床推广。

Objective：To explore Shoutai Pill treated luteal phase defect threatened abortion and its effect on cytokines. Methods：Collected our hospital 86 cases patients of luteal phase defect threatened abortion,according to random number table method were randomly divided into control group and treatment group,43 cases in each group. The control group was given intramuscular injection of progesterone injection,oral administration of progesterone tablets and other treatment;The treatment group based on the control group was given Shoutai Pill. Two groups of patients were treated for 2 weeks with 1 course of treatment. Compared the clinical efficacy of the two groups. The lumbar acid abdominal pain relieves time and the bleeding time were compared between the two groups. The levels of P,HCG,E2 and the serum IL-17,IL-10,TNF-α levels were compared between the two groups. Results：After the treatment,the total clinical efficiency rate of the treatment group was 93.02%,and the total clinical effective rate of the control group was 74.42%. The treatment group improved significantly compared with the control group,the difference was statistically significant（P〈0.05）;The lumbar acid abdominal pain relieves time and the bleeding time in two groups were shortened,the treatment group compared with the control group shortened significantly,the difference was statistically significant（P〈0.05）;The levels of P,HCG,E2 in two groups were increased,the treatment group compared with the control group increased significantly,the difference was statistically significant（P〈0.05）;The levels of IL-17,IL-10,TNF-α were decreased in two groups,the treatment group compared with the control group decreased more obviously（P〈0.05）. Conclusion：The Shoutai Pill have the effect of tonifying kidney and preventing miscarriage,tonifying Qi and strengthening spleen,harmonizing Chong and Ren channels. It has a good clinical effect on the two deficiency of spleen and kidney of luteal phase defect threatened abortion. It is worthy to clinical promotion.