酸枣仁汤治疗冠心病合并失眠患者疗效及对生存质量影响

Effect of Suanzaoren Decoction on Treating Patients with Coronary Heart Disease Complicated with Insomnia and Its Influence on Quality of Life

目的：探讨酸枣仁汤治疗冠心病合并失眠患者的疗效及对生存质量的影响。方法：采用病例对照研究的方法选取2017年1月—2017年10月于我院住院的106例冠心病患者,所有患者均伴有不同程度失眠症状。将患者按随机数字表分配,治疗组53例,对照组53例,其中对照组患者进行常规西医治疗,治疗组患者则在西医基础治疗的同时使用酸枣仁汤,两组患者均治疗1个月。治疗结束后计算临床总有效率,观察患者失眠情况评分、中医症状积分及生存质量。结果：两组患者临床疗效显著,对照组临床总有效率为64.15%,治疗组临床总有效率为85.90%,表明治疗组总有效率较高,有统计学意义（P〈0.05）;应用匹兹堡睡眠质量指数量表（PSQI）、睡眠状况自评量表（SRSS）对两组患者进行检测,结果显示两组患者的PSQI、SRSS评分明显低于治疗前,治疗组患者的PSQI、SRSS评分显著低于对照组（P〈0.05）;应用生存质量评定量表（WHOQOL）测评患者治疗后生存质量,结果显示治疗后两组患者生存质量明显提高,治疗组患者生存质量优于对照组（P〈0.05）;监测两组患者心胸隐痛、失眠多梦、倦怠懒言等中医症状改善情况,治疗后两组患者中医症状积分均有所改善,治疗组患者中医症状积分较对照组患者明显降低,差异具有统计学意义（P〈0.05）。结论：酸枣仁汤具有养血除烦、养心安神的作用,可以明显改善冠心病患者失眠症状,提高患者生存质量,临床上值得应用。

Objective：To explore the curative effect of Suanzaoren Decoction on treating patients with coronary heart disease complicated with insomnia and its influence on quality of life. Methods：A casecontrol study was conducted in 106 patients with coronary heart disease from January 2017 to October 2017 in our hospital. All the patients were accompanied with different degrees of insomnia. According to the random number table,there were 53 cases in the experimental group and 53 cases in the control group. All the patients in the two groups were treated for 1 month. Results：The clinical efficacy of the two groups was significant,the total effective rate of the control group was 64.15%,the total effective rate of the experimental group was 85.90%,which indicated that the total effective rate of the experimental group was higher,with statistical significance（P〈0.05）. Pittsburgh sleep quality index（PSQI）,selfrating scale of sleep（SRSS）were used to test the sleep status of the two groups. The results showed the PSQI,SRSS scores of the two groups were significantly lower than before treatment,the scores of PSQI,SRSS in the experimental group were significantly lower than those in the control group（P〈0.05）. The quality of life（QOL）was evaluated by WHOQOL. The results showed that the quality of life of the two groups was significantly improved after treatment. The quality of life in the experimental group was better than that in the control group（P〈0.05）. Monitoring the improvement of TCM symptoms such as chest pain,insomnia and dream,burnout and lazy speech,the scores of TCM symptoms in two groups after treatment were improved,the experimental group decreased more significantly than those in control group,the difference was statistically significant（P〈0.05）. Conclusion：Suanzaoren Decoction has the effect of nourishing blood and removing annoyance,nourishing the heart and soothing the mind,which can obviously improve the insomnia symptoms and the quality of life of the patients with coronary heart disease. It is worth of clinical application.