摘要
Janus激酶(JAK)是一种非受体酪氨酸蛋白激酶,参与体内众多重要的生物学过程,是一条重要的细胞内信号转导通路。研究表明,由其介导的通路通常与炎症性疾病、皮肤性疾病及其他自身免疫性疾病有关,JAK已逐渐成为治疗这些疾病的重要靶标。主要综述了JAK的结构与功能、JAK-STAT信号通路在治疗RA中的调控作用以及近年来JAK抑制剂的研究进展,旨在为以JAK为靶点的药物研发提供参考。
Janus kinase （JAK）, a non-receptor tyrosine kinase, participated in many important biological processes m vivo and was an important intracellular signal transduction pathway. It was observed that the pathways mediated by JAKs were associated with inflammatory diseases, dermatologic diseases, and other autoimmune diseases, and JAKs were the important targets for the treatment of these diseases. This review mainly discussed the structure and function of JAKs, and the role of the JAK-STAT signaling inhibitors in recent years was also described, focusi based on JAK. pathway in treating RA. Meanwhile, the development of JAK ng on providing effective reference for researching new drugs based on JAK.
作者
张溢凡
ZHANG Yi-fan(Health Unit of 93575 Troop,People＇s Liberation Army of China,Chengde 067000,China)
出处
《精细化工中间体》
CAS
2018年第3期10-14,共5页
Fine Chemical Intermediates
