氧化溴代合成(E)-2-溴甲基-α-甲氧亚胺基苯乙酸甲酯的研究

Synthesis of(E)-2-Bromomethyl-α-methoxyiminophenylacetic Acid Methyl Ester by Oxidative Bromination

考察了氢溴酸/双氧水氧化溴代法合成(E)-2-溴甲基-α-甲氧亚胺基苯乙酸甲酯的反应规律。优化反应条件为:反应温度80℃,偶氮二异丁腈(AIBN)作引发剂,n(原料)∶n(H2O2):n(HBr)=1.00∶1.20∶1.05,优化条件下,收率达88.2%。且用溴化钠-硫酸代替氢溴酸,合成(E)-2-溴甲基-α-甲氧亚胺基苯乙酸甲酯的收率为88.2%。

The synthetic process of （E）-2-bromomethyl-α-methoxyiminophenylacetic acid methyl ester by hydrobromic acid/hydrogen peroxide oxidation bromination was investigated. The optimal reaction conditions were as follows： 80℃, AIBN as the initiator, n（raw material）：n（H2O2）：n（HBr）=1.O0：1.20：1.05, and the yield was 88.2%. The yield of methyl （E）-2-bromomethyl-α-methoxyiminophenylacetate was found to be 88.2% with sodium bromide- sulfuric acid instead of hydrobromic acid.