摘要
考察了氢溴酸/双氧水氧化溴代法合成(E)-2-溴甲基-α-甲氧亚胺基苯乙酸甲酯的反应规律。优化反应条件为:反应温度80℃,偶氮二异丁腈(AIBN)作引发剂,n(原料)∶n(H2O2):n(HBr)=1.00∶1.20∶1.05,优化条件下,收率达88.2%。且用溴化钠-硫酸代替氢溴酸,合成(E)-2-溴甲基-α-甲氧亚胺基苯乙酸甲酯的收率为88.2%。
The synthetic process of (E)-2-bromomethyl-α-methoxyiminophenylacetic acid methyl ester by hydrobromic acid/hydrogen peroxide oxidation bromination was investigated. The optimal reaction conditions were as follows: 80℃, AIBN as the initiator, n(raw material):n(H2O2):n(HBr)=1.O0:1.20:1.05, and the yield was 88.2%. The yield of methyl (E)-2-bromomethyl-α-methoxyiminophenylacetate was found to be 88.2% with sodium bromide- sulfuric acid instead of hydrobromic acid.
作者
罗春艳
黄超群
张荣
尹笃林
LUO Chun-yan;HUANG Chao-qun;ZHANG Ron;YIN Du-lin(National & Local Joint Engineering Laboratory for New Petro-chemical Materials and Fine Utilization of Resources,Hunan Normal University,Changsha 410081,China;Changsha Jia Qiao Biological Technology Co.,Ltd.,Changsha 410205,China)
出处
《精细化工中间体》
CAS
2018年第3期18-20,共3页
Fine Chemical Intermediates
基金
国家自然科学基金项目(21776068)
关键词
氢溴酸
溴化钠
双氧水
溴代
hydrobromicacid
sodiumbromide
hydrogen peroxide
bromination