神经酰胺在胰岛β细胞凋亡中作用的研究进展
摘要
胰岛β细胞凋亡是糖尿病发生及进展的重要机制,研究表明神经酰胺在β细胞凋亡中发挥了重要作用。它通过激活内质网应激、内/外源性细胞凋亡途径、改变线粒体膜通透性诱导β细胞凋亡,同时介导ROS/RNS、炎症因子等细胞毒作用,使胰岛β细胞进一步丢失、胰岛素分泌减少。本文就神经酰胺在胰岛β细胞凋亡过程所发挥的作用作一综述。
出处
《现代临床医学》
2018年第5期321-323,326,共4页
Journal of Modern Clinical Medicine
基金
河北省医学科学研究重点课题(20160744)
二级参考文献17
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