溴隐亭应用于妊娠合并高泌乳素血症患者对其妊娠结局的影响

Effect of bromocriptine on pregnancy outcome in pregnant women with hyperprolactinemia

目的探讨溴隐亭对妊娠合并高泌乳素血症患者的妊娠结局的影响。方法回顾性分析2015年1月-2017年6月收治的84例患有高泌乳素血症的妊娠患者的诊疗情况。按照患者孕早期是否服用溴隐亭,将研究对象分为对照组(44例)和观察组(40例)。随访观察2组患者至妊娠结束,比较2组患者的流产发生率、流产发生后的保胎成功率和妊娠结局。结果观察组患者总流产发生率(15.00%)明显低于对照组(43.18%),2组比较差异有统计学意义(P<0.05)。观察组先兆流产患者的保胎成功率(92.86%)明显高于对照组(61.54%),2组比较差异有统计学意义(P<0.05)。观察组保胎成功至足月阴道分娩率(41.18%)明显高于对照组(16.00%),2组比较差异有统计学意义(P<0.05);2组早产儿、低体质量儿、新生儿窒息的发生率差异无统计学意义(P>0.05)。结论溴隐亭孕期应用能明显改善妊娠合并高泌乳素血症患者的妊娠结局,降低流产发生率,提高保胎成功率,建议在临床推广应用。

Objective To investigate the effect of bromocriptine on pregnancy outcome in pregnant women with hyperprolactinemia.Methods The clinical data of 84 pregnant women with hyperprolactinemia from January 2015 to June 2017 were retrospectively analyzed.Patients were divided into control group（44 cases）and observation group（40 cases）according to whether they took bromocriptine in the first trimester of pregnancy.Two groups of patients were followed up to the end of pregnancy.The incidence of abortion,the success rate of fetus after abortion,the outcome of pregnancy and the level of serum hormone in the two groups were compared.Results The incidence of total abortion in the observation group（15.00%）was significantly lower than that in the control group（43.18%）,and the difference between the two groups was statistically significant（P 0.05）.The success rate of fetal abortion in the observation group（92.86%）was significantly higher than that in the control group（61.54%）,and the difference between the two groups was statistically significant（P 0.05）.The success rate of fetal vaginal delivery（41.18%）in the observation group was significantly higher than that of the control group（16.00%）,and the difference between the 2 groups was statistically significant（P 0.05）.There was no significant difference in the incidence of premature infants,low birth weight infants and neonatal asphyxia between the 2 groups（P 0.05）.Conclusion The application of bromocriptine during pregnancy can obviously improve the pregnancy outcome of pregnancy with hyperprolactinemia,reduce the incidence of abortion,improve the rate of fetal success,and do not increase the risk of pregnancy and newborn.It is suggested to be widely used in clinical practice.