摘要
衰老是一种在细胞和组织水平逐渐发生功能衰退的过程.早衰症是一类罕见的人类遗传性疾病,以加速衰老为特征.对早衰症的研究有助于理解人类衰老的生理过程,对衰老相关疾病的防治具有借鉴意义.成人早衰症和儿童早衰症是两种著名的人类早衰症,本文将综述这两种早衰症的发病机制及干预方法.
Aging is a process of gradual functional deterioration at the cellular and organismal level. Progeroid syndromes represent a group of rare genetic disorders with features of premature aging. Werner syndrome（WS）and Hutchinson-Gilford progeria syndrome（HGPS） are two of the best characterized human progeroid syndromes.The study of premature aging is helpful to understand the physiological processes of human aging and is useful for the prevention and treatment of aging-related diseases. This review focuses on the mechanisms and potential therapeutic interventions of these two progeroid diseases.
作者
王泽华
李洪宇
曲静
张维绮
刘光慧
WANG Ze-Hua;LI Hong-Yu;QU Jing;ZHANG Wei-Qi;LIU Guang-Hui(State Key Laboratory of Stem Cell and Reproductive Biology,Institute of Zoology,Chinese Academy of Sciences,Beijing 100101,China;National Laboratory of Biomacromolecules,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China;Institute of Stem cell and Regeneration,Chinese Academy of Sciences,Beijing 100101,China)
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2018年第9期926-934,共9页
Progress In Biochemistry and Biophysics
基金
中国科学院战略性先导科技专项(XDA16010100)
国家重点基础研究发展计划(973)(2015CB964800
2017YFA0103304
2017YFA0102802
2014CB910503
2014CB964600
2018YFA0107203)
国家自然科学基金(91749202
31471394
31671429
91749123
81625009
81330008
81371342
81471414
81422017
81601233
81671377
31601109
31601158
81771515
81701388
31571533
31621004
81822018)资助项目~~
