伊伐布雷定对冠状动脉粥样硬化性心脏病心绞痛患者左心室功能的影响

Effect of Ivabradine Tablets on Left Ventricular Function in Patients with Coronary Heart Disease and Angina Pectoris

目的探讨伊伐布雷定片对冠状动脉粥样硬化性心脏病(简称冠心病)心绞痛患者左心室功能的影响。方法选取心血管医院2012年3月至2017年3月收治的冠心病心绞痛患者62例,按随机数字表法均分为研究组和对照组,各31例。对照组患者给予酒石酸美托洛尔片治疗,研究组患者在对照组治疗基础上加用伊伐布雷定片。结果治疗后,两组患者心绞痛发作次数、酒石酸美托洛尔总用量、心绞痛持续时间均较治疗前明显减少或缩短(P <0. 05),左心室射血分数(LVEF)显著升高,左心室舒张末期内径(LVEDd)、左心室收缩末期容量(LVESV)显著下降,且治疗后研究组变化较对照组明显(P <0. 05);两组药品不良反应发生情况无明显差异(P> 0. 05)。结论伊伐布雷定片治疗冠心病心绞痛临床疗效显著,可显著改善患者左心室功能。

Objective To investigate the effect of Ivabradine Tablets on left ventricular function in patients with coronary heart disease and angina pectoris. Methods Totally 62 patients with coronary heart disease and angina pectoris admitted to a hospital from March 2012 to March 2017 were selected and divided into the study group and the control group according to the random number table method, 31 cases in each group. The control group was treated with Metoprolol Tartrate Tablets, on this basis, the study group was additionally treated with Ivabradine Tablets. Results After treatment, the frequency of angina attack, the total dosage of metoprolol tartrate and angina duration in the two groups were significantly reduced or shortened（ P 〈 0. 05）, the LVEF in the two groups was significantly increased, the LVEDd and LVESV in the two groups were significantly decreased, and the changes in the study group were more significant than those in the control group（P 〈 0. 05）. There was no significant difference in the incidence of adverse drug reactions between the two groups（P 〉 0. 05）. Conclusion Ivabradine Tablets are effective in the treatment of coronary heart disease and angina pectoris, which can significantly improve left ventricular function in patients.