养胃颗粒对实验性胃溃疡的治疗作用研究

Studies on the therapeutical effect of Yangwei granules for experimental gastric ulcer

目的研究养胃颗粒对实验性鼠胃溃疡的治疗作用。方法分别采用水浸应激性大鼠胃溃疡、乙酸烧灼性大鼠胃溃疡、吲哚美辛致小鼠胃溃疡、利血平致小鼠胃溃疡等4种胃溃疡动物模型,考察养胃颗粒对胃溃疡的治疗作用;采用乙酸引起小鼠扭体反应动物模型,考察养胃颗粒的镇痛作用。结果养胃颗粒灌胃给药对4种模型动物的胃溃疡均具有较好的保护效果,可以减轻胃黏膜损伤程度,降低溃疡指数,抑制溃疡形成,减少溃疡发生率;对乙酸引起小鼠扭体反应模型动物具有较好的镇痛效果,可以减少乙酸引起小鼠扭体反应的扭体次数。结论养胃颗粒具有明显的治疗实验性胃溃疡的作用,可以用于胃及十二指肠等消化性溃疡的治疗。

Objective To study the therapeutic effects of Yangwei granules on experimental gastric ulcer.MethodsFour animal models of experimental gastric ulcer included water immersion stress and acetic acid induced gastric ulcer in rats,indomethacin and reserpine induced gastric ulcer in mice were used to observe the therapeutical effects of Yangwei granules on experimental gastric ulcer.The animal model of acetic acid induced writhing reaction test in mice was used to observe the analgesia effect.Results Yangwei granules of gavage administration had good protection effect on four animal models of experimental gastric ulcer.It reduced the degree of gastric mucosa damage and the ulcer index,inhibited the ulcer formation and lowered the ulcer incidence.It also had significant analgesic effect with reduced numbers of writhing reaction in mice model induced by acetic acid.Conclusion Yangwei granules had noticeable therapeutic effects for experimental gastric ulcer.It can be used to treat gastric and duodenal peptic ulcers.