前列地尔脂微球注射液临床超说明书用药干预分析

Interventional analysis on the off-label drug use of alprostadil lipid microsphere injection

目的调查第二军医大学附属长海医院前列地尔脂微球注射液的应用情况,分析其临床应用合理性,评价医院行政干预在促进临床合理用药中的作用。方法以2016年7月28日医院行政干预为界限,对2016年7月和8月共计1 351例使用本品的患者,统计其所在科室、临床诊断、前列地尔的用法用量。结果本品在医院各科室广泛应用,65.41%的病例出现了超适应证用药的情况,99.85%的病例存在超说明书用法用量的情况,0.39%的病例出现了禁忌证用药的情况,医院行政干预前后结果近乎一致。结论超说明书应用本品的情况在临床广泛存在,应当引起临床重视,仅实施行政干预的效果较差。

Objective To investigate the application of Lipo-PEG1 injection in our hospital,analyze the rationality of its clinical application and evaluate the role of the administrative intervention in promoting the rational drug use in the hospital.Methods Based on the administrative guidelines announced on July 28,2016,the data from 1 351 patients who received LipoPEG1 injection during July and August were collected and analyzed.Results Lipo-PEG1 injection is widely used in different departments at the hospital.65.41%cases received this medication as off-label indications.99.85%cases used this drug with impropriate dosage and indications.0.39% cases had contraindications.There was no difference before and after the administrative intervention.Conclusion The off-label use of Lipo-PEG1 injection is very common in clinical practice.More clinical attention should be paid to this problem.The results from simple administrative intervention is unsatisfied.