口干患者218例唇腺免疫球蛋白G4表达情况

Expression of IgG4 in labial glands of 218 patients with dry mouth

目的免疫球蛋白(Ig)G4^+细胞在口干患者唇腺中的表达情况。方法以是否患有原发性干燥综合征(p SS),将口干的218例患者分为p SS组和单纯口干组,并应用En Vision法对其唇腺行Ig G4免疫组织化学染色,观察2组患者Ig G4^+细胞的浸润水平。结果单纯口干组唇腺Ig G4表达强度明显低于p SS组(P<0.01);患者唇腺Ig G4免疫组织化学结果与其活检病理的分级呈正相关关系(r=0.284,P<0.01);结论当口干主诉患者的唇检结果示:唇腺组织中淋巴细胞的浸润量高于2灶/4 mm^2时,该患者的唇腺Ig G4免疫组织化学阳性率较高,这对临床中初步筛查p SS合并Ig G4相关性疾病有一定的指导意义。

Objective To investigate the expression of IgG4^＋ cells in the labial glands of patients with dry mouth. Methods A total of 218 patients were divided into primary Sjogren＇s syndrome （pSS） group and simple mouth dry group according to whether they were diagnosed with pSS. Envision method was used to perform the immunohistoehemieal staining of IgG4 in the labial glands, and the infiltration level of IgG4^＋ cells in both groups was determined. Results The expression intensity of IgG4 in the labial gland of the simple dry mouth group was significantly lower than that of the pSS group （P〈0.01）. The findings of IgG4 immunohistoehemistry of the labial glands showed a positive correlation with the grading of biopsy pathology （r=0.284, P〈0.01 ）. Conclusion The findings of the labial gland biopsy in patients complained of dry mouth show that the positive rate of IgG4 immunohistoehemistry in the labial gland is higher when the lymphocyte infiltration involves more than two lesions/4 mm^2 in the labial gland tissue. This can be clinically relevant for preliminary screening of pSS complicated with IgG4-related diseases.