摘要
细胞凋亡是程序性细胞死亡的普遍形式,当发生改变时,会引起人类许多疾病。Bcl-2和相关蛋白是一种调节细胞凋亡的分子家族,与许多人类疾病特别是癌症的发生有密切的关系。针对Bcl-2靶点的相关药物中,Venetoclax已经上市,AT-101、BCL-201等已进入临床研究阶段。
The apoptosis is the common form of programmed cell death, when it changes, many diseases can be caused. Bcl-2 and related protein is a molecule family of adjusting the apoptosis, which is closely related to the occurrence of human diseases especially the cancer. In the related drugs of Bcl-2 target points, Venetoclax has been listed,and AT-101 and BCL-201 has entered into the clinical research stages.
作者
寇玉辉
张英俊
谢洪明
林兴龙
许娟
KOU Yu-hui;ZHANG Ying-jun;XIE Hong-ming;LIN Xing-long;XU Juan(National Key Laboratory for Research and Development of Anti infection New Drugs East Sunshine Pharmaceutical(Co,Ltd),Dongguan,Guangdong Province,523871 China)
出处
《系统医学》
2018年第13期193-195,共3页
Systems Medicine
基金
中国博士后科学基金
新结构的Smac模拟物设计
合成及抗肿瘤活性研究(NO.2016M592459)
广东省引进创新创业团队项目资助(2016ZT06Y616)