Bcl-2蛋白及其相关药物的研究进展

Research Process of Bcl-2 Protein and Related Drugs

细胞凋亡是程序性细胞死亡的普遍形式,当发生改变时,会引起人类许多疾病。Bcl-2和相关蛋白是一种调节细胞凋亡的分子家族,与许多人类疾病特别是癌症的发生有密切的关系。针对Bcl-2靶点的相关药物中,Venetoclax已经上市,AT-101、BCL-201等已进入临床研究阶段。

The apoptosis is the common form of programmed cell death, when it changes, many diseases can be caused. Bcl-2 and related protein is a molecule family of adjusting the apoptosis, which is closely related to the occurrence of human diseases especially the cancer. In the related drugs of Bcl-2 target points, Venetoclax has been listed,and AT-101 and BCL-201 has entered into the clinical research stages.