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血清瘦素、脂联素与冠心病痰瘀互阻证的关系探讨

Relationship between Serum Leptin,Adiponectin and Phlegm and Blood Stasis Syndrome in Coronary Heart Disease
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摘要 目的探讨血清瘦素、脂联素与冠心病痰瘀互阻证的关系。方法选取2016年1月—2016年12月平顶山市第二人民医院心内科住院行冠状动脉造影的病人160例(观察组),按照中医辨证分型分为痰瘀互阻证组50例与非痰瘀互阻证组70例,冠状动脉造影正常病人40例(正常对照组),分别检测3组病人血清瘦素水平与脂联素水平。结果观察组血清瘦素明显高于对照组(P <0.05),脂联素明显低于对照组(P <0.05);痰瘀互阻证组血清瘦素明显高于非痰瘀互阻证组(P <0.05),脂联素明显低于非痰瘀互阻证组(P <0.05);冠状动脉造影结果中病变支数越多,血清瘦素水平越高(P <0.05),脂联素水平越低(P <0.05)。结论血清瘦素、脂联素水平可反映冠状动脉粥样硬化的程度,血清瘦素、脂联素水平可能与痰瘀互阻存在一定关系。 Objective To investigate the correlation between serum leptin (LP),adiponectin (APN),and phlegm and blood stasis syn -drome of coronary heart disease (CHD).Methods One hundred and sixty patients who underwent coronary angiography (CAG) in theDepartment of Cardiology,Second People ′ s Hospital of Pingdingshan from January 2016 to December 2016 were enrolled as observa -tion group.According to traditional Chinese medicine (TCM) syndrome differentiation,the patients were divided into phlegm and bloodstasis syndrome group ( n =50),non phlegm and blood stasis syndrome group ( n =70).Forty patients with normal CAG were asnormal controls.The levels of serum LP and APN were detected.Results The level of serum LP in the observation group was signifi-cantly higher than that in the control group (P 〈0.05),and serum APN level was significantly lower than that in the control group (P 〈0.05).The serum leptin level in the phlegm and blood stasis syndrome group was significantly higher than that in the non phlegm andblood stasis syndrome group (P 〈0.05),and the adiponectin level was significantly lower than that in the non phlegm and blood stasissyndrome (P 〈0.05).CAG showed that the serum LP level gradually increased and APN level gradually decreased with the increase〈in the branches of coronary artery lesion (P 〈0.05).Conclusion Serum LP and APN levels may reflect the degree of coronary ather -osclerosis.Serum leptin and adiponectin levels may be related to the pathogenesis of phlegm and blood stasis syndrome.
作者 李满生 张领 蔡华 张晓华 李新峰 岳修宇 陈军军 Li Mansheng;Zhang Ling;Cai Hua;Zhang Xiaohua;Li Xinfeng;Yue Xiuyu;Chen Junjun(The Second People ′ s Hospital of Pingdingshan,Pingdingshan 467099,Henan,China)
出处 《中西医结合心脑血管病杂志》 2018年第17期2530-2533,共4页 Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
基金 河南省卫生科技创新型人才工程专项经费资助项目[No.豫卫科(2010)40]
关键词 冠心病 痰瘀互阻证 冠状动脉造影 血清瘦素 脂联素 血脂 coronary heart disease phlegm and blood stasis syndrome coronary angiography serum leptin adiponectin blood lipid
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