布地奈德、福莫特罗联合治疗老年哮喘并COPD的临床效果及对炎症反应影响分析

Analysis of Clinical Effect of Budesonide Combined with Formoterol in Treatment of Senile Asthma Combined with COPD and Effect on the Inflammatory Reactions

目的探索布地奈德、福莫特罗联合治疗老年哮喘并COPD的临床效果及对炎症反应影响。方法选取2015年10月—2016年10月期间该院老年哮喘并COPD的100例患者,抽签化分组(各50例),对照组和观察组分别采用常规西药治疗和布地奈德联合福莫特罗治疗,随后对比两组患者的IL-6、IL-4、TNF-α、hs-CRP、FEV1、FEV1/FVC、PaCO_2、总有效率。结果观察组患者的IL-6(5.17±1.31)pg/m L、IL-4(61.03±3.62)pg/m L、TNF-α(2.11±0.12)pg/m L、hs-CRP(4.12±0.63)mg/L、FEV1(2.67±0.42)L、FEV1/FVC(11.48±1.69)%、Pa CO2(6.13±0.29)Kpa、总有效率(96.00%)均优于对照组(t=6.271 4、18.862 0、10.055 9、7.785 2、11.519 7、4.800 1、17.450 9、χ~2=17.420 1;P<0.05)。结论对老年哮喘并COPD患者实施布地奈德联合福莫特罗治疗效果显著。

Objective To explore the clinical effect of budesonide combined with formoterol in treatment of senile asthma combined with COPD and effect on the inflammatory reactions.Methods 100 cases of senile asthma patients with COPD in our hospital from October 2015 to October 2016 were selected and divided into two groups with 50 cases in each,the control group used the routine western medicine,while the observation group were treated with budesonide combined with formoterol,and the IL-6,IL-4,TNF-α,hs-CRP,FEV1,FEV1/FVC,PaCO2 and total effective rate were compared between the two groups.Results The IL-6（5.17±1.31）pg/m L,IL-4（61.03±3.62）pg/m L,TNF-α（2.11±0.12）pg/m L,hs-CRP（4.12 ±0.63） mg/L,FEV1（2.67 ±0.42）L,FEV1/FVC（11.48 ±1.69） %,Pa CO2（6.13 ±0.29）Kpa,total effective rate96.00% in the observation group were better than those in the control group（t=6.271 4,18.862 0,10.055 9,7.785 2,11.519 7,4.800 1,17.450 9,χ2=17.420 1;P〈0.05）.Conclusion The implementation effect of budesonide combined with formoterol in treatment of senile asthma combined with COPD patients is obvious.