染料木素的结构修饰及活性研究进展

Progress in Structure Modification and Activity of Genistein

该文对染料木素结构修饰及活性方面的研究进展进行了综述，包括染料木素的糖苷化，烷基化，羟基化，酯化，磺化等多种修饰，并讨论了结构修饰对染料木素生物活性的影响，包括抗肿瘤活性，抑菌活性等。目前，染料木素的结构修饰及衍生主要集中在C-5位酚羟基，C-7位酚羟基以及C-8上，所得的衍生物大多表现出较母体结构更好的生物活性。该文总结了现有结构修饰的不足之处，并对染料木素结构改造的发展方向进行了展望。

In this paper, the progress of modification and activity of genistein was reviewed, including glycosylation, alkylation, hydroxylation, esterification, sulfonation and so on. Furthermore, the effects of structural modification on biological activity such as antitumor and antibacterial activities were discussed. At present, the structural modification and derivation of genistein mainly concentrated on the 5-phenolic hydroxyl, 7-phenolic hydroxyl and C8, and most of the derivatives had better biological activity than genistein. At the same time, the insufficiency of existing structure modification of genistein was summarized, Finally, the development trend of structural modification of genistein was presented.