表观遗传修饰对突触可塑性的调控作用研究进展

Progress on Regulation Synaptic Plasticity by Epigenetic Modification

突触可塑性被认为是学习记忆细胞水平的生物学基础,与学习记忆密切相关。最近的研究表明,表观遗传修饰如DNA甲基化和组蛋白翻译后修饰在调节突触可塑性中发挥重要作用,这一发现不仅有助于进一步阐释学习记忆复杂的机制,更有利于为记忆相关疾病的诊治提供新思路。论文介绍了表观遗传修饰机制的基本背景,并就表观遗传修饰在调控突触可塑性及认知功能障碍中的作用进行综述。

Synaptic plasticity is considered to be the biological basis of learning and memory at the cellular level, and is closely related to learning and memory.Recent studies have shown that epigenetic mechanisms such as DNA methylation and histone post-translational modifications play an important role in the regula- tion of synaptic plasticity.This finding will not only help to explain the complex mechanism of learning and memory,but also provide new ideas to the diagnosis and treatment of memory-related diseases.This paper introduced the basic concept of epigenetic modification mechanism,and mainly focused on the role of epige- netic modification in the regulation of synaptic plasticity and cognitive dysfunction in recent years.