超敏C反应蛋白与急性心力衰竭患者预后的关系

Correlation Between Hypersensitive C-Reactive Protein and Prognosis in Patients with Acute Heart Failure

目的:探讨超敏C反应蛋白(hs–CRP)与急性心力衰竭患者预后之间的关系,为今后的临床诊疗工作提供参考。方法:选取阳江市人民医院2016年1月至2016年12月收治的136例急性心力衰竭患者作为观察对象,所有患者入院后均行hs–CRP检测,并根据检测结果将其分为正常组(57例)与异常组(79例),所有患者均给予常规治疗,治疗1个月后比较两组患者的临床总有效率、脑钠肽(BNP)、hs–CRP以及左室舒张末期内径(LVEDD)和左室射血分数(EF)。结果:(1)治疗后,正常组中显效21例、有效29例、无效7例,总有效率为87.71%;异常组中显效17例、有效39例、无效23例,总有效率为70.89%;正常组明显高于异常组,差异具有统计学意义(P<0.05)。(2)治疗后,正常组的BNP、EF水平均明显高于异常组,组间比较,差异具有统计学意义(P<0.05);正常组hs–CRP及LVEED水平均明显低于异常组,组间比较,差异具有统计学意义(P<0.05)。结论:hs–CRP水平异常的急性心力衰竭患者与预后密切相关,其临床治疗效果与预后明显低于正常水平患者。

Objective To investigate the correlation between the Hypersensitive C-reactive protein（hs–CRP） and the prognosis of patients with acute heart failure, provide a reference for clinical work in the future. Methods In the department of cardiology in Yangjiang people＇s hospital 136 cases of patients with acute heart failure in hospital during the period from January 2016 to December 2016 as the group of observation samples, all patients were admitted to the hospital for hs–CRP detection, and according to the results of the test will be divided into the normal group（57 cases） and abnormal group（79 cases）, all patients were given conventional treatment combined with propafenone treatment, after 1 months of treatment, compared two groups of patients with clinical total efficiency, brain natriuretic peptide（BNP）, hs–CRP and left ventricular end diastolic diameter（LVEDD） and left ventricular ejection fraction（EF）. Results（1） after treatment, markedly effective in normal group 21 cases, 29 cases were effective, 7 cases ineffective, the total effective rate was 87.71 %; in 17 cases, markedly abnormal group, 39 cases were effective, 23 cases ineffective, the total the effi ciency is 70.89 %; the normal group was higher than abnormal group, with statistical signifi cance, P〈0.05.（2） after the treatment, the normal group of BNP, EF were signifi cantly higher than the abnormal group, with statistical signifi cance, P〈0.05; hs–CRP and normal LVEED levels were signifi cantly lower than the control group, with statistical signifi cance, P〈0.05. Conclusion the prognosis of patients with acute heart failure level of high sensitive C-reactive protein abnormality is closely related to the clinical treatment effect and prognosis of patients was signifi cantly lower than the normal level.