摘要
人三磷酸腺苷结合盒转运蛋白A1(ABCAl)基因呈高度多态性。启动子区(rs2422493、rs2740483等)及编码区(rs2230806、rs4149313等)的一些多态性位点与冠心病相关。ABCAl基因多态性与冠心病的关联机制,一方面通过影响血浆高密度脂蛋白胆固醇及其他脂质水平;另一方面可能通过改变ABCAl蛋白结构及功能。现就ABCAl基因多态性与冠心病的相关性及机制进行综述。
The human adenosine triphosphate-binding cassette transporter A1 (ABCA1)gene is highly polymorphic. Some polymorphisms in promoters (rs2422493, rs2740483, etc. ) and exons (rs2230806, rs4149313, etc. )have been reported to be significantly associated with coronary heart disease(CHD). In terms of the underlying mechanisms, ABCA1 gene polymorphisms might be associated with CHD through modulating the levels of high-density lipoprotein cholesterol and other lipids,or through changing ABCA1 protein structure and function. In this article, the association of ABCA1 gene polymorphisms with CHD and the underlying mechanisms are reviewed.
作者
罗至
吕湛
宋永砚
Luo Zhi;Lyu Zhan;Song Yongyan(Department of Cardiology,Affiliated Hospital of North Sichuan Medical College,Nanehong 637000,China(Luo Z,L yu Z;Department of Medical Biochemistry,North Sichuan Medical College,Nanchong 637000,China(Song YY)Corresponding author :Luo Zhi,Email : 2454912230 @qq.com)
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2018年第9期1051-1054,共4页
Chinese Journal of Geriatrics
基金
四川省教育厅重点项目(17ZA0172)
南充市校合作科研专项(NSMC20170403)
关键词
载脂蛋白类
多态性
单核苷酸
冠状动脉疾病
Carrier proteins
Polymorphism,single nucleotide
Coronary heart disease