摘要
晚期糖基化终末产物（advanced glycation end-products, AGEs）是在非酶条件下，蛋白质、脂类或核酸等大分子物质的游离氨基与还原糖的醛基发生一系列反应，生成的一种有害的稳定化合物。孕妇体内增多的AGEs与体内高血糖环境、氧化应激、胰岛素抵抗密切相关，其在妊娠期糖尿病的发生、发展过程中发挥重要作用。本文主要围绕AGEs与妊娠期糖尿病的发病机理进行论述。
Advanced glycation end-products （AGEs） are stable and toxic by-products of non-enzymatic metabolic reaction of proteins, lipids and nucleotides. The elevated serum AGEs level in pregnant women is strongly associated with hyperglycemia, oxidative stress and insulin resistance and may be one of the cause for the onset and development of the gestational diabetes mellitus （GDM） . This review mainly focuses on the pathogenesis of AGEs and GDM.
作者
刘诗羽
付佳鑫
孟宜波
彭兰兰
陈惠
肖雪
姚远
Liu Shiyu;Fu Jiaxin;Meng Yibo;Peng Lanlan;Chen Hui;Xiao Xue;Yao Yuan(Department of Obstetrics and Gynaecology,West China Second University Hospital,Key Laboratory of Birth Defects and Related Diseases of Women and Children,Sichuan University,Ministry of Education,Chengdu 610041,China;Department of Obstetrics and Gynaecology,Meishan City People＇s Has-pital,Meishan 620010,China;Department of Obstetrics and Gynaecology,Ziyang Maternal and Child Health Hospital,West China Second University Hospital Regional Union Hospital,Ziyang 641300,China)
出处
《中华内分泌外科杂志》
CAS
2018年第4期345-347,352,共4页
Chinese Journal of Endocrine Surgery
基金
四川省科技支撑计划（2014SZ0001）
