冠心病合并2型糖尿病患者Tp-e间期与Tp-e/QT比值的研究

Study on Tp-e interval and Tp-e/QT ratio in the patients with coronary heart disease complicated with type 2 diabetes mellitus

目的探讨2型糖尿病合并冠心病患者QT间期、Tp-e间期和Tp-e/QT检测的临床价值。方法随机选取冠心病合并2型糖尿病50例,分别与年龄、性别与之匹配的体检组、2型糖尿病、冠心病患者各50例进行比较,分别测量四组V4导联QT间期、Tp-e间期、计算Tp-e/QT。结果 (1)冠心病合并2型糖尿病组与体检组对比QT间期、Tp-e间期和Tp-e/QT比值差异有统计学意义(P<0.05)。(2)冠心病合并2型糖尿病组与2型糖尿病组、冠心病组对比,Tp-e间期和Tp-e/QT比值均显著高,差异有统计学意义(P<0.05)。(3)冠心病合并2型糖尿病组与冠心病组、2型糖尿病组比较,QT间期差异无统计学意义(P>0.05)。结论 Tp-e间期与Tp-e/QT比值比QT间期在预测室性心律失常更有价值;Tp-e间期和Tp-e/QT可作为冠心病合并2型糖尿病患者发生恶性心律失常的预测指标。

Objective To investigate the clinical value of QT interval, Tp-e interval and Tp-e/QT detection in the patients with type 2 diabetes mellitus complicated with coronary heart disease. Methods 50 patients with coronary heart disease complicated with type 2 diabetes were randomly selected and were compared with 50 cases of physical examination group, type 2 diabetes and coronary heart disease respectively who matched the age and gender. Four sets of V4 lead QT and Tp-e intervals were measured, and Tp-e/QT was calculated. Results （1）The difference of QT interval, Tp-e interval and Tp-e/QT ratio between coronary heart disease complicated with type 2 diabetes group and physical examination group was statistically significant（P〈0.05）. （2）The coronary heart disease complicated with type 2 diabetes group was compared with type 2 diabetes group and coronary heart disease group, the Tp-e interval and Tp-e/QT ratio was significantly higher, and the difference was statistically significant（P〈0.05）. （3）There was no statistically significant difference in QT interval between coronary heart disease complicated with type 2 diabetes group and coronary heart disease group and type 2 diabetes group（P〉0.05）. Conclusion Tp-e interval and Tp-e/QT ratio is more valuable than QT interval in predicting ventricular arrhythmia; Tp-e interval and Tp-e/QT can be used as predictors of malignant arrhythmia in patients with coronary heart disease complicated with type 2 diabetes.