内源性外泌体作为纳米载药系统在心肌缺血治疗中的研究进展

Research progress of endogenous exosomes as nano drug delivery system for treatment of myocardial ischemia

外泌体是一种由活细胞分泌的天然纳米微囊泡,是细胞间信息传递、物质交换的重要媒介。作为人体内源性载体,外泌体负载药物具有毒性低、无免疫原性、渗透性好、靶向性高等优点。在过去几年中,外泌体作为药物载体已成功负载小分子化学药物、核酸、蛋白质等。此外,这一新型载体也有望为临床治疗心肌缺血提供有力支持。该文就外泌体作为治疗心肌缺血载体的研究进展进行综述。

Exosomes are natural nano vesicles secreted by living cells, which play an important role in cellular communication and substance transportation. As a kind of carrier of human endogenous for drug transportation, many advantages of exosomes are in sight, for example, low toxicity, non immunogenicity, good permeability and high-targeting. In recent years, small molecular chemical drugs, nucleic acids and proteins have been successfully delivered by exosomes. This novel carrier is expected to provide strong support for the clinical treatment of myocardial ischemia. The research progress of exosomes as a kind of carrier in the treatment of myocardial ischemia was briefly summarized in this article.