恶性血液肿瘤患者侵袭性真菌感染防治进展

Prevention and treatment for invasive fungal infection in patients with hematological malignancies

侵袭性真菌感染是恶性血液肿瘤患者常见的并发症之一,并导致较高的病死率,由此受到越来越多的关注。近十年来,随着诊疗模式的逐步完善,初级预防及二级预防的建立,新型抗真菌药物的应用,其发病率较前下降,但死亡率仍高。合理有效的防治可降低血液病患者真菌感染相关死亡率。该综述简述了恶性血液病患者中侵袭性真菌病预防、治疗策略的更新及目前真菌治疗存在的问题。

Invasive fungal infection is one of the common complications in patients with malignant blood tumor, which leads to a high mortality rate. Over the past decade, with the gradual improvement of the diagnosis and treatment, the establishment of primary and secondary prevention, and the application of new antifungal drugs, the incidence of the disease is lower than before, but the mortality is still high. Reasonable and effective prevention and treatment can reduce the mortality of fungal infection in patients with hematological malignancies. This review summarizes the prevention, treatment strategies and existing problems of invasive fungal disease in patients with hematological malignancies.