分子诊断儿童耐药结核病研究进展

Research progress of molecular diagnosis in pediatric drug-resistant tuberculosis

近些年来随着儿童耐药结核病发生率的增高,儿童结核病作为威胁全球儿童公共健康的严重疾病越来越受到广大儿科医师的关注.由于儿童结核病灶内结核杆菌含量很低,常常不能引起典型的临床症状及影像学表现,同时＂金标准＂结核分枝杆菌（MTB）检测耗时长,且阳性率低,使儿童结核病不能得到及时诊断和治疗,儿童结核的分子诊断技术因其快速、准确、高效、操作简便等显著优点而得到广泛的临床应用和发展,以期为儿童耐药结核分子诊断提供帮助.

With the increasing of incidence rate of pediatric drug-resistant tuberculosis in recent years,pe-diatric tuberculosis as a threat to global childhood public health was serious disease and attracted more and more pediatrician concern. Pediatric tuberculosis often can′t result to typical clinical symptoms and imaging findings because its quantity of tubercle bacillus was little in lesions of infection,meanwhile,golden standard mycobacterium tuberculosis detection was time-consuming and low positive rate,pediatric tuberculosis can′t get timely diagnosis and therapy,mo-lecular diagnostic techniques of pediatric drug-resistant tuberculosis got widely clinical application and development for its advantage of rapid,accurate,efficiency and easy operation etc,several common molecular diagnostic techniques in pediatric drug-resistant tuberculosis were summarized,which would provide useful guidance for molecular diagnose of pediatric drug-resistant tuberculosis.