摘要
本文采用中波紫外照射的人皮肤成纤维细胞(HSF)和人永生化皮肤角质形成细胞(HaCaT)细胞衰老模型,探索了红景天的4种萃取物—红景天总皂苷、总黄酮、多糖和挥发油的体外抗皮肤衰老作用。结果显示所试的4种萃取物都具有与浓度相依的抗衰老作用,其效果顺序依次为皂苷>多糖>黄酮>挥发油。其中,浓度为800μg/m L的皂苷的抗衰老效果是维生素C对照组的2倍。黄酮和多糖对HSF细胞具有相当的修复效果,且都好于挥发性油;在HaCaT细胞的场合多糖、黄酮和挥发油具有相类似的抗衰老效果。可见红景天的不同粗提物对人皮肤细胞有一定的抗衰老修复能力,这为深入地研发红景天抗衰老、抗辐射产品提供一定的理论依据。
The anti-aging effect of four extracts（saponins, flavonoids, polysaccharides and volatile oils） from Rhodiola was investigated using the anti-aging model with damaged human skin fibroblasts（HSF） and Human immortalized keratinocytes（HaCaT） cells irradiated by medium-wavelength UV. The results showed that the test four extracts exhibited a concentration-dependent anti-aging effect on HSF and HaCaT cells, with the decreasing activity in the order： saponins polysaccharides flavonoids volatile oils. The anti-aging activity of saponins at 800 μg/m L was 2 times that of the control（Vc）. Flavonoids and polysaccharides have the similar repairing effects on demaged HSF cell, which were better than volatile oils. In the case of the Ha Ca T cell, polysaccharides, flavonoids and volatile oils had the same anti-aging effects. Therefore, it could be concluded that different extracts of Rhodiola have an anti-aging ability to repair demaged human skin cell, which may provide a theoretical basis for the development of Rhodiola products with anti-aging and anti-radiation activities.
作者
周思思
姜建国
ZI-IOU Si-si;JIANG Jian-guo(College of Food Science and Engineering,South China University of Technology,Guangzhou 510640,China)
出处
《现代食品科技》
EI
CAS
北大核心
2018年第8期16-23,共8页
Modern Food Science and Technology
基金
广州市科技计划项目(201604020150)
