婴幼儿肺炎25羟维生素D水平及免疫相关因素的研究

Study on the 25 Hydroxy Vitamin D Levels and Immune Related Factors in Infants with Pneumonia

目的:探讨婴幼儿肺炎患者的25羟维生素D及免疫水平之间的相关性。方法:分别收集泉州市儿童医院2016年8月—2017年7月,1~6个月重症肺炎患儿50例,普通肺炎患儿50例,健康婴幼儿50例;7个月~2岁重症肺炎患儿50例,普通肺炎患儿50例,健康婴幼儿50例。分别测定25羟维生素D水平、体液免疫水平、细胞免疫水平,并收集相关临床资料包括(日晒情况、活动量、既往呼吸道感染史)进行统计分析。结果:重症肺炎组25羟维生素D平均水平低于普通肺炎组及健康组(P<0.05),普通肺炎组低于健康组(P<0.05)。细胞免疫水平,重症肺炎组低于普通肺炎组及健康组(P<0.05),普通肺炎组与健康组差异无统计学意义(P>0.05)。体液免疫水平Ig M 3组间差异无统计学意义(P>0.05),Ig A重症肺炎组低于同龄普通肺炎组及健康组(P<0.05),普通组低于健康组(P<0.05),Ig G重症肺炎组低于同龄普通肺炎组及健康组(P<0.05),普通肺炎组与健康组的差异无统计学意义(P>0.05)。重症肺炎组日晒少、活动量少、既往呼吸道感染史发生率高于普通肺炎组及健康组(P<0.05),普通肺炎组高于健康组(P<0.05)。结论:25羟维生素D水平不足与婴幼儿肺炎有关,其可能影响婴幼儿的体液免疫水平及细胞免疫水平,维生素D缺乏是重症肺炎的危险因素。

Objective： To investigate the correlation between 25 hydroxy vitamin D and immune level in infants and infants with pneumonia. Methods： The children’s hospital of quanzhou city collected 50 cases of severe pneumonia from August 2016 to July 2017,50 cases of common pneumonia,and 50 cases of healthy infants and young children from 1 to 6 months.From 7 months to 2 years old,50 cases of severe pneumonia,50 cases of common pneumonia,and 50 cases of healthy infants and young children. The levels of 25 hydroxy vitamin D,humoral immunity, and cell immunity were measured respectively,and relevant clinical data were collected,including（sun exposure,activity,and history of past respiratory infections） for statistical analysis. Results： The average level of 25 hydroxy vitamin D in the severe pneumonia group was lower than that in the common pneumonia group and the healthy group （ P 〈0.05）,while that in the common pneumonia group was lower than that in the healthy group （ P 〈0.05）.The level of cellular immunity in severe pnenmonia group was lower than that in common pneumonia group and healthy group （ P 〈0.05）,and there was no significant difference between common pneumonia group and healthy group （ P 〉0.05）.There was no significant difference in the level of humoral immunity in IgM three groups （ P 〉0.05）.IgA of the severe pneumonia group was lower than the same age common pneumonia group and the healthy group （ P 〈0.05）,the common pneumonia group was lower than the healthy group （ P 〈0.05）,IgG of the severe pneumonia group was lower than the common pneumonia group and the healthy group in same age （ P 〈0.05）,and there was no significant difference between the common pneumonia group and the healthy group （ P 〉0.05）.The incidence of severe pneumonia in the severe pneumonia group was higher than that of the normal pneumonia group and the health group （ P 〈0.05）.The common pneumonia group was higher than that of the healthy group （ P 〈0.05）. Conclusion： The deficiency of 25 hydroxy vitamin D is associated with pneumonia in infants and infants, which may affect the level of humoral immunity and cellular immunity in infants and infants, and vitamin D deficiency is a risk factor for severe pneumonia