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EGFR-TKI序贯化疗治疗EGFR-TKI获得性耐药晚期非小细胞肺癌的临床分析 被引量:1

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摘要 目的:分析EGFR-TKI序贯化疗治疗EGFR-TKI获得性耐药晚期非小细胞肺癌的效果。方法:选取我院2015年10月—2016年10月接诊的获得性耐药晚期非小细胞肺癌患者20例,按照化疗模式的不同将其分为研究组和对照组,每组10例。研究组患者进行EGFR-TKI序贯化疗治疗,对照组患者进行单纯化疗,对比两组患者在接受化疗之后的肿瘤标志物水平、治疗效果和不良反应。结果:近期效果:研究组治疗总有效率高于对照组(P<0.05);远期效果:研究组生存时间长于对照组(P<0.05);肿瘤标志物:研究组CEA、NSE、CYFRA21-1水平均比对照组低(P<0.05);不良反应:研究组不良反应发生率低于对照组(P<0.05)。结论:对EGFR-TKI获得性耐药晚期非小细胞肺癌使用序贯治疗,无论是从近期效果还是远期效果均高于单纯化疗治疗,且不良反应相对较少,安全性较高。
作者 余芳
出处 《医学理论与实践》 2018年第18期2749-2750,共2页 The Journal of Medical Theory and Practice
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  • 1抗癌药急性及亚急性毒性反应分度标准(WHO)[J].癌症,1992, 11(7): 2.
  • 2Jemal A,Siegel R,Xu J,et al.Cancer statistics,2010[J].CA Cancer J Clin,2010,60(5):277-300.
  • 3Jackman D,Pao W,Riely GJ,et al.Clinical definition of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer[J].J Clin Oncol,2010,28(2):357-360.
  • 4Kuo CH,Lin SM,Lee KY,et al.Subsequent chemotherapy improves survival outcome in advanced non-small-cell lung cancer with acquired tyrosine kinase inhibitor resistance[J].Clin Lung Cancer,2010,11(1):51-56.
  • 5Wu JY,Shih JY,Yang CH,et al.Second-line treatments alter first-line gefitinib therapy in advanced nonsmall cell lung cancer[J].Int J Cancer,2010,126(1):247-255.
  • 6Mok TS,Wu YL,Yu CJ,et al.Randomized,placebocontrolled,phaseⅡstudy of sequential erlotinib and chemotherapy as first-line treatment for advanced non-small-cell lung cancer[J].J Clin Oncol,2009,27(30):5080-5087.
  • 7Socinski MA,Bondarenko I,Karaseva NA,et al.Weekly nabpaclitaxel in combination with carboplatin versus solventbased paclitaxel plus carboplatin as first-line therapy in patients with advanced non-small-cell lung cancer:final results of a phaseⅢtrial[J].J Clin Oncol,2012,30(17):2055-2062.
  • 8Inoue A,Kobayashi K,Maemondo M,et al.Updated overall survival results from a randomized phaseⅢtrial comparing gefitinib with carboplatin-paclitaxel for chemo-nave nonsmall cell lung cancer with sensitive EGFR gene mutations(NEJ002)[J].Ann Oncol,2013,24(1):54-59.
  • 9Mitsudomi T,Morita S,Yatabe Y,et al.Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor(WJTOG3405):an open label,randomised phase 3trial[J].Lancet Oncol,2010,11(2):121-128.
  • 10Maemondo M,Inoue A,Kobayashi K,et al.Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR[J].N Engl J Med,2010,362(25):2380-2388.

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